肠球菌万古霉素耐药基因簇遗传特性  

Genetic characteristics of vancomycin resistance gene cluster in Enterococcus spp

作　　者：陈春辉[1] 徐晓刚[1] 

机构地区：[1]复旦大学附属华山医院抗生素研究所,卫生部抗生素临床药理重点实验室,上海200040

出　　处：《遗传》2015年第5期452-457,共6页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:81171613)资助

摘　　要：万古霉素耐药肠球菌自20世纪80年代后期被发现以来,已逐渐发展成为重要的医院感染病原菌。此类耐药肠球菌携带的万古霉素耐药基因簇编码产物可催化合成与万古霉素、替考拉宁等糖肽类抗生素亲和力极低的细胞壁前体导致耐药。目前已在肠球菌中发现的万古霉素耐药基因簇根据基因序列及构成不同分为9个型别;依据它们编码的连接酶合成产物不同又可分为D-Ala:D-Lac连接酶基因簇(Van A、Van B、Van D及Van M型)和D-Ala:D-Ser连接酶基因簇(Van C、Van E、Van G、Van L和Van N型)。这些耐药基因簇介导的耐药水平及其传播模式各有特点。文章综述了肠球菌中万古霉素耐药基因簇的类型、基因构成及传播特性。Vancomycin resistant enterococci has become an important nosocomial pathogen since it is discovered in late 1980s. The products, encoded by vancomycin resistant gene cluster in enterocoeci, catalyze the synthesis of peptidoglycan precursors with low affinity with glycopeptide antibiotics including vancomycin and teicoplanin and lead to resistance. These vancomycin resistant gene clusters are classified into nine types according to their gene se- quences and organization, or D-Ala：D-Lac （VanA, VanB, VanD and VanM） and D-Ala：D-Ser （VanC, VanE, VanG, VanL and VanN） ligase gene clusters based on the differences of their encoded ligases. Moreover, these gene clusters are characterized by their different resistance levels and infection models. In this review, we summarize the classification, gene organization and infection model of vancomycin resistant gene cluster in Enterococcus spp.

关 键 词：肠球菌属 万古霉素 耐药 基因簇 

分 类 号：R446.5[医药卫生—诊断学]