HMGB1和MMP-9在食管鳞癌组织中的表达及临床意义  

Expressions and clinical significance of HMGB1 and MMP-9 in esophageal squamous cell carcinoma

作　　者：赵国军[1,2] 黄俊星[1] 于鸿[3] 吴静[1] 詹树东 姚娟[1] 张思慧[1,2] 焦霞[3] 

机构地区：[1]南通大学附属泰州市人民医院肿瘤科,江苏省225300 [2]南通大学医学院 [3]南通大学附属泰州市人民医院病理科,江苏省225300

出　　处：《江苏医药》2015年第9期1017-1019,共3页Jiangsu Medical Journal

基　　金：江苏省卫生厅科技项目(H201260)

摘　　要：目的探讨高迁移率族蛋白B1(HMGB1)和基质金属蛋白酶-9(MMP-9)在食管鳞癌组织中的表达及临床意义。方法采用免疫组化EnVision法检测食管鳞癌组织(A组,87例)和癌旁正常黏膜组织(B组,40例)中HMGB1和MMP-9的表达。结果 A组HMGB1和MMP-9阳性表达率均高于B组(69.0%vs.22.5%和62.1%vs.12.5%)(P<0.05)。A组HMGB1和MMP-9阳性表达与肿瘤浸润深度、TNM分期有关(P<0.05)。A组HMGB1和MMP-9表达呈正相关(rs=0.295,P<0.01)。结论联合检测食管鳞癌组织中HMGB1和MMP-9蛋白表达可能有助于评估食管鳞癌的恶性程度。Objective To explore the expressions and clinical significance of high mobility group protein box 1 （ HMGB1 ） and matrix metalloproteinase-9 （ MMP-9 ） in esophageal squamous cell carcinoma （ESCC）. Methods The expressions of HMGB1 and MMP-9 were detected by immunohistochemical EnVision method in ESCC tissues （group A, 87 cases） and tumor-adjacent normal mucosal tissues（group B, 40 cases）. Results The positive expression rates of HMGB1 and MMP-9 in group A were significantly higher than those in group B（69. 0% vs. 22.5% and 62. 1% vs. 12.5%） （P〈0. 05）. The positive expressions of HMGB1 and MMP-9 in group A were closely related to the depth of tumor invasion and TNM stage（P〈0. 05）. The expression of HMGB1 in group A was positively correlated with that of MMP-9 （r,=0. 295,P〈0. 01）. Conclusion Combined detection of the expressions of HMGB1 and MMP-9 may be beneficial to evaluating the malignancy of ESCC.

关 键 词：高迁移率族蛋白B1 基质金属蛋白酶9 食管鳞癌 

分 类 号：R735[医药卫生—肿瘤]