组织因子与循环肿瘤细胞  

Tissue factor and circulating tumor cells

作　　者：栾利昆[1] 杨之斌[1] 谭晶[1] 

机构地区：[1]昆明医科大学第三附属医院大肠癌中心,云南昆明650118

出　　处：《肿瘤》2015年第5期592-596,共5页Tumor

基　　金：国家自然科学基金资助项目(编号:30960445);云南省科技计划项目(编号:2012FB071;2013FB166)~~

摘　　要：循环肿瘤细胞(circulating tumor cells,CTCs)是肿瘤转移和复发的根源。研究提示,组织因子(tissue factor,TF)可作为CTCs的一个新的标志物。本文综述了TF在促进CTCs形成及激活肿瘤细胞增殖、存活、免疫逃逸和肿瘤血管形成等过程中的作用及其机制,探讨靶向TF/CTCs治疗肿瘤策略的研究现状及面临的挑战,为靶向TF/CTCS治疗肿瘤策略的应用提供理论基础。Circulating tumor cells（CTCs） is the source of tumor metastasis and recurrence.Many studies have suggested that tissue factor（TF） can be used as a novel marker of CTCs.This review focuses on the effects of TF on promotion of formation of CTC,activation of tumor cell proliferation,tumor cell survival,tumor angiogenesis and immune escape of tumor as well as its mechanisms;it also discusses the current status of TF/CTCs-targeted strategy in tumor treatment and the challenges faced,in hope of providing the theoretical basis for the application of TF/CTCs-targeted strategy in this field.

关 键 词：肿瘤循环细胞 凝血致活酶 肿瘤逃逸 靶向治疗 

分 类 号：R730.23[医药卫生—肿瘤]