V-cGAPs： attenuators of 3＇3＇-cGAMP signaling  

作　　者：Pu Gao Dinshaw J Patel 

机构地区：[1]Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065,USA

出　　处：《Cell Research》2015年第5期529-530,共2页细胞研究（英文版）

摘　　要：Cyclic GMP-AMPs （cGAMPs） are new members of the cyclic dinucleo- tide family of second messenger signaling molecules identified in both bacteria and mammalian cells. A recent study by Gao et al. published in Cell Research has identified and characterized three 3＇3＇-cGAMP-specific phosphodiesterases （termed as V-cGAP1/2/3） in V. cholerae, thereby providing mechanistic insights into the function of these enzymes that degrade cGAMPs.

关 键 词：信号传导分子 衰减器 细胞识别 磷酸二酯酶 第二信使 哺乳动物 GAO 酶降解 

分 类 号：Q42[生物学—神经生物学] TN715[生物学—生理学]