药物经皮吸收数学模型研究进展  

Progress of mathematical modeling for trandermal drug absorption

作　　者：何星垚 王晖[1] 

机构地区：[1]广东药学院中药学院,广东广州510006

出　　处：《中国药理学通报》2015年第5期596-600,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81072591);广东省科技计划项目(No 2012B060300030)

摘　　要：经皮给药是一种能避免肝脏的首过效应及肠胃灭活、维持血药浓度、提高生物利用度的给药途径。而药物经皮吸收需透过角质层、活性表皮层、真皮层的屏障。近年来,随着计算机技术的发展,根据药物的不同理化特性及皮肤各层的生理特征,建立了许多预测药物经皮吸收方面的数学模型。该文就预测药物经皮吸收数学模型的研究进展进行了综述。Transdermal drug delivery is an administration route which can avoid the first-pass effect,maintain steady plasma concentrations and enhance bioavailability. Drug transporting through the skin by passage through the stratum corneum leads to the viable epidermis and the dermis.With the development of the computer technology,many mathematical models for predic-ting the absorption of drugs have been built according to physical and chemical properties of drugs and physiological characteristics＆nbsp;of each skin layer.This article presented provides a summary of the progress of mathematical models for predicting percutaneous absorption of drugs.

关 键 词：经皮吸收 透皮吸收 预测药物经皮吸收 数学模型 透皮系数 经皮给药 经皮转运 

分 类 号：R-05[医药卫生] R322.99