参与肺动脉平滑肌细胞增殖信号转导机制及信号转导抑制剂的研究进展  

Advances in research on signal transduction mechanisms and their inhibitors for the proliferation of pulmonary artery smooth muscle cells

作　　者：李明星[1] 王勇[1] 蒋德旗[1,2] 王艳[1] 喻珊珊[1] 

机构地区：[1]南方医科大学珠江医院药剂科,广东广州510282 [2]玉林师范学院生物制药教研室,广西玉林537000

出　　处：《中国药理学通报》2015年第5期605-610,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81200043);广东省自然科学基金资助项目(No S2013040014251)

摘　　要：肺动脉高压是一种以肺血管阻力升高为特征,最终导致右心功能严重受限、衰竭甚至死亡的慢性进展性疾病。其组织病理学改变主要以肺血管重构为特点,而肺动脉平滑肌细胞在外周血管的异常增殖是肺血管重构的主要病理基础。该文主要对参与肺动脉平滑肌细胞增殖信号转导机制及信号转导抑制剂的研究进展作一综述。Pulmonary artery hypertension （PAH ） is a chronic progressive disease characterized by a persistent elevation of pul-monary vascular pressure,and the disease would limit the right ventricular function severely,fail the organ and even lead to death in the end.The histopathological change of PAH is fea-tured by the restructuring of pulmonary vessels,and the abnor-mal reproduction of pulmonary artery smooth muscle cells （PASMCs）in peripheral vessels is the major pathological basis＆nbsp;of pulmonary vascular restructuring.This paper mainly reviews the research advances on signal transduction mechanisms and their inhibitors in promoting the proliferation of pulmonary artery smooth muscle cells.

关 键 词：肺动脉高压 肺动脉平滑肌细胞 增殖 信号转导机制 信号转导抑制剂 进展 

分 类 号：R-05[医药卫生] R322.121