microRNA在肝癌诊治中的研究进展  

Progress of microRNA in diagnosis and treatment of hepatocellular carcinoma

作　　者：邱历伟[1] 潘刘翃 姚登福[1] 

机构地区：[1]南通大学附属医院医学实验中心,江苏南通226001

出　　处：《胃肠病学和肝病学杂志》2015年第5期501-505,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家国际科技合作专项(2013DFA32150)

摘　　要：microRNA(miRNA)是一类内源性染色体上的非编码单链RNA,通过翻译抑制或降解靶mRNA在转录后水平调控基因表达。miRNA在发育、细胞分化、增殖、凋亡、病毒感染及癌变等多种病理、生理过程中起重要作用。miRNA直接参与肝癌的发生、发展,与肝癌的诊断、转移、预后和靶向治疗等相关。本文就近年miRNA与肝癌研究的新进展作一概述。microRNAs are non-coding single stranded RNAs in endogenous chromosome that regulate gene expression post-transcritionally through degradation or inhibition translation of target mRNA. miRNAs play important roles in many pathologic functions, such as development, cell differentiation or proliferation, apoptosis, virus pathogenesis, and onco- genesis, miRNAs directly participate in the occurrence and development of hepatocellular carcinoma （HCC） and are as- sociated with the diagnosis, metastasis and prognosis of HCC. This review summarized new progress of the relationship between miRNAs and HCC.

关 键 词：肝细胞癌 MICRORNA 诊断 转移 预后 

分 类 号：R735.7[医药卫生—肿瘤]