异甘草酸镁治疗药物性肝炎过程中IL-6和PCT的变化  

Changes of IL-6 and PCT in drug-induced liver inflammation treated by magnesium isoglycyrrhizinate

作　　者：洪金鹏[1] 王兆林[2] 王俊科 晏双龙[3] 于晓辉[3] 白德成[1] 

机构地区：[1]兰州大学基础医学院,甘肃兰州730050 [2]兰州大学第二医院 [3]兰州军区兰州总医院消化科

出　　处：《胃肠病学和肝病学杂志》2015年第5期547-548,552,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：甘肃省自然基金(0803RJZA059)

摘　　要：目的分析异甘草酸镁注射液治疗药物性肝炎(drug-induced liver inflammation,DILI)过程中IL-6和PCT的变化,探讨IL-6和PCT对病情及预后判断的影响。方法收集31例DILI患者清晨空腹静脉血,用罗氏免疫分析试剂盒检测异甘草酸镁用药前后IL-6和PCT的变化。结果异甘草酸镁治疗DILI前后IL-6和PCT的差异有统计学意义(P<0.05)。结论异甘草酸镁能明显改善DILI患者的肝功能,IL-6和PCT可以作为判断其疗效的有效血清学指标。Objective To analyze the changes of IL-6 and PCT in drug-induced liver inflammation （DILI） treated by magnesium isoglycyrrhizinate, and investigate the role of IL-6 and PCT in the judgement of treament and prognosis. Methods The fasting venous blood of 31 patients with DILI were collected, and the changes of IL-6 and PCT were ana- lyzed by Roche immunoassay test kit before and after the treatment by magnesiumi soglycyrrhizinate. Results Differ- ences of IL-6 and PCT in 31 patients before and after the treatment by magnesium isoglycyrrhizinate were statistically sig- nificant （P 〈 0.05）. Conclusion Magnesium isoglycyrrhizinate can significantly improve liver function in patients with DILI,IL-6 and PCT can serve as effective serological markers to determine efficacy.

关 键 词：异甘草酸镁 药物性肝炎 白细胞介素-6 降钙素原 

分 类 号：R575[医药卫生—消化系统]