血浆同型半胱氨酸及高敏C反应蛋白与阵发性心房颤动消融术后复发的关系  

Correlation of high-sensitivity C-reactive protein and homocysteine levels with recurrence of paroxysmal atrial fibrillation after catheter ablation

作　　者：李根林[1] 江华[1] 李菊香[1] 俞建华[1] 陈琦[1] 鲍慧慧[1] 胡建新[1] 洪葵[1] 吴延庆[1] 

机构地区：[1]江西南昌大学第二附属医院心内科,330006

出　　处：《中华心律失常学杂志》2015年第2期118-120,共3页Chinese Journal of Cardiac Arrhythmias

基　　金：科技部863课题（2012AA02A516）;江西省赣鄱“555”人才计划

摘　　要：目的 探讨血浆同型半胱氨酸（HCY）及高敏C反应蛋白（hs-CRP）水平与阵发性心房颤动（房颤）导管消融术后复发的关系.方法 连续选取2011年7月至2013年1月在南昌大学第二附属医院接受导管消融治疗的阵发性房颤患者126例,检测患者术前及术后1年血浆HCY和hs-CRP水平,随访1年后根据房颤复发情况分为复发组和非复发组.结果 房颤复发组血浆HCY和hs-CRP水平无论是术前还是术后均高于非复发组（P＜0.05）.非复发组血浆HCY与hs-CRP的水平均有下降趋势,而复发组却为上升趋势,并且血浆HCY与hs-CRP的水平呈正相关[（r=0.49,P＜0.01）,（r=0.41,P＜0.01）].结论 血浆HCY和hs-CRP与阵发性房颤导管消融术后复发密切相关,随访中两者水平不降低对其复发有一定的预测价值.Objective To investigate the relationship of high-sensitivity C-reactive protein （hs-CRP） and homocysteine levels with recurrence of paroxysmal atrial fibrillation after catheter ablation.Methods A total of 126 patients with paroxysmal atrial fibrillation underwent radiofrequency catheter ablation.All patients were followed up for 1 year and were allocated to non-recurrence group or recurrence group according to recurrence of atrial fibrillation or not.Plasma levels of hs-CRP and homocysteine were determined before procedure and at one-year follow-up.Results Plasma hs-CRP and homocysteine levels pre-and post-procedure were higher in recurrence group than that in Non-recurrence group.Plasma hs-CRP and homocysteine in non-recurrence group had a downward trend,while the recurrent group had a rising trend.And we had found that the plasma levels of hs-CRP were positively correlated with homocysteine.Conclusions The levels of hs-CRP and homocysteine are closely correlated with recurrence of paroxysmal atrial fibrillation after catheter ablation.It is valuable to measure hs-CRP and homocysteine for predicting recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation.

关 键 词：心房颤动 射频导管消融 同型半胱氨酸 高敏C反应蛋白 

分 类 号：R541.75[医药卫生—心血管疾病]