乳腺癌患者外周血叶酸及维生素D的变化及临床意义  

Changes and clinical significance of folic acid and vitamin D in peripheral blood of breast cancer patients

作　　者：高翠红[1] 高庆双[1] 韩秀青[1] 薛书保 肖凤艳[1] 赵玉萍[1] 赵丽梅[1] 

机构地区：[1]河北省唐山市妇幼保健院检验科,063000 [2]唐山市古冶区医院

出　　处：《中国妇幼保健》2015年第17期2722-2723,共2页Maternal and Child Health Care of China

基　　金：唐山市科技计划项目〔14130245a〕

摘　　要：目的:分析乳腺癌患者血清叶酸(FA)、维生素D(Vit D)水平,探讨二者与乳腺癌相关临床因素的关系。方法:选择乳腺癌患者45例,35例乳腺良性肿瘤患者和30例健康体检者做对照,取空腹静脉血采用电化学发光法检测3组FA、Vit D水平,并进行相关的统计学分析。结果:FA、Vit D水平乳腺癌组明显低于乳腺良性肿瘤组和正常对照组,差异有统计学意义(P<0.05);乳腺良性肿瘤组与正常对照组FA、Vit D水平差异无统计学意义(P>0.05)。癌症组FA、Vit D随着临床分期的升高而递减。结论:血清叶酸和维生素D含量与乳腺癌发生风险和TNM分期有关,高水平的FA、Vit D可能会降低乳腺癌的发病风险。Objective ： To analyze the levels of serum folic acid and vitamin D ill breast cancer patients, explore their relationships with related clinical factors of breast cancer. Methods： Forty-five breast cancer patients, thirty-five breast benign tumor patients, and thirty healthy women after healthy physical examination were selected, fasting venous blood specimens were obtained to detect the levels of serum folic acid and vitamin D by electro-chemiluminescence immunoassay, related statistical analysis was conducted. Results： The levels of serum folio acid and vitamin D in breast cancer group were statistically significantly lower than those in breast benign tumor group and normal control group （ P〈0.05 ） ; there was no statistically significant difference in the levels of serum folic acid and vitamin D between breast benign tumor group and normal control group （P〉0.05） . The levels of serum folic acid and vitamin D in breast cancer group decreased with the increase of clinical stage. Conclusion： The levels of serum folic acid and vitamin D are correlated with risk of breast cancer and TNM stage, high levels of serum folic acid and vitamin D may reduce the risk of breast cancer.

关 键 词：乳腺癌 叶酸 维生素D 

分 类 号：R737.9[医药卫生—肿瘤]