前列腺疾病史与中国人群前列腺癌发病关系的Meta分析  

A Meta analysis of the relationship between the medical history of prostatosis and the onset of prostate cancer among Chinese population

作　　者：沈兴蓉 程静[1] 沙蕊[1] 王德斌[1] 

机构地区：[1]安徽医科大学卫生管理学院,安徽合肥230032

出　　处：《中国农村卫生事业管理》2015年第5期625-627,共3页Chinese Rural Health Service Administration

摘　　要：目的:探讨前列腺炎与前列腺增生与中国人群前列腺癌发病的关系。方法:检索Pubmed、中国生物医学文献数据库(CBM)、中国知网、万方数据库从建库到2015年1月31日的文献,对所纳入的独立研究,运用Stata12进行Meta分析。结果:共纳入前列腺炎研究6篇,均为病例对照研究,累计样本量为1 389,其中病例组566例,对照组823例;前列腺增生文献5篇,累计样本量为929,其中病例组428例,对照组501例。Meta分析结果表明,前列腺炎与前列腺癌研究的6篇文献异质性较小,选用固定效应模型,合并相对危险度OR及95%CI值为4.55(3.40,6.11)。前列腺增生与前列腺癌研究的5篇文献异质性较大选用随机效应模型,合并OR值及95%CI为3.50(2.19,5.59)。结论:前列腺炎、前列腺增生是前列腺癌发生的危险因素。Objective To explore the relationship between prostatitis, benign prostatic hyperplasia and prostate cancer. Methods We searched for data on case control study or cohort study published from the time of establishment of database up to January 31 , 2015 regarding the relationship between prostatitis, benign prostatic hyperplasia and prostate cancer from Pubmed, CBM, CNKI and Wanfang database. We performed Meta analysis by the Stata 12 software after extraction and quality evaluation. Results A total of 6 studies on prostatitis containing 566 cases and 823 controls and 5 ones on benign prostatic hyperplasia including 428 cases and 501 controls were analyzed. Q statistics test revealed low total heterogeneity between the 6 studies on prostatitis and prostate cancer. And the pooled OR value was 4. 55 （3.40,6. 11 ） using fixed effect model. However, the Q statistics test found high total heterogeneity between the 5 papers on benign prostatic hyperplasia and prostate cancer. And the combined OR value was3. 50 （2. 19,5. 59） using random effect model. Conclusions Prostatitis and benign prostatic hyperplasia are the risk factors of prostate cancer.

关 键 词：前列腺癌 前列腺增生 前列腺炎 META分析 

分 类 号：R737.25[医药卫生—肿瘤]