加兰他敏治疗轻度认知障碍的临床研究  

Clinical research of galanthamine in the treatment of mild cognitive impairment

作　　者：林鸿[1] 高宏章[1] 陈荣平[1] 杨文明[1] 

机构地区：[1]湛江市遂溪县人民医院,524300

出　　处：《中国实用医药》2015年第14期1-2,共2页China Practical Medicine

基　　金：湛江市科技局医学类科技攻关项目(项目编号:2011C105034)

摘　　要：目的对加兰他敏治疗轻度认知障碍的临床效果进行评估,对其安全性进行评价。方法轻度认知障碍患者100例,随机分成实验组及对照组,每组50例,对照组按照传统方法治疗,实验组在此基础上增加加兰他敏治疗,分别于治疗后3个月对患者认知功能及肝、肾等功能进行评价。结果实验组简易精神状态量表(MMSE)评分较对照组显著升高(P<0.05);对照组肝、肾功能指标与实验组比较,差异无统计学意义(P>0.05)。结论加兰他敏联合传统治疗,能够显著改善患者认知功能,且对患者肝肾功能无明显毒副作用。Objective To evaluate the clinical effect by galanthamine in the treatment of mild cognitive impairment, and to evaluate its safety.Methods A total of 100 mild cognitive impairment patients were randomly divided into experimental group and control group, with 50 cases in each group. The control group received traditional methods for treatment, and the experimental group received additional galanthamine. In 3 months after treatment, their cognitive function, liver and kidney functions were evaluated.Results The experimental group had remarkably improved mini-mental state examination （MMSE） score, comparing with that of the control group （P〈0.05）; and the control group had no statistically significant differences of liver and kidney functions with the experimental group （P〉0.05）.Conclusion Combination of galanthamine and traditional treatment can significantly improve cognitive function of patients, and this method has no obvious toxic and side effects for liver and kidney functions.

关 键 词：加兰他敏 轻度认知障碍 疗效 

分 类 号：R749.1[医药卫生—神经病学与精神病学]