N,N',N″-三(亚磷酸三乙酯)缩甲膦酸亚氨二乙酸及苦味酸铕配合物的合成及其与BSA相互作用的研究  

Synthesis and Interaction with BSA of N,N',N″-tri( triethylphosphite) A Reduction Iminodiacetic Acid Phosphate and Complexes

作　　者：宋盼[1] 杨水兰[1] 刘伟[1] 杨天林[1] 

机构地区：[1]宁夏大学化学化工学院能源重点实验室,宁夏银川750021

出　　处：《化学试剂》2015年第6期487-494,共8页Chemical Reagents

基　　金：国家自然科学基金资助项目(21261018);教育部科学基金重点资助项目(208195)

摘　　要：设计合成了一种新型含磷的水溶性三足体衍生标题化合物,用红外光谱、差热-热重、元素分析及连续摩尔比法对其结构和组成进行了表征和分析,确定了三足体衍生物与苦味酸铕形成了1∶1型配合物Eu(pic)3L。综合运用紫外-可见光谱、循环伏安法及荧光光谱法研究了标题配合物与牛血清白蛋白(BSA)的相互作用。实验结果表明:苦味酸铕配合物与BSA形成1∶1型无荧光复合物Eu(pic)3L-BSA,其荧光猝灭方式表现为静态猝灭,结合位点数为1,作用力类型为氢键和范德华力。A novel of water-soluble phosphorus-containing tripod ligand [ N, N＇, N＂-tri（triethylphosphite） a reduction iminodiace- tic acid phosphate] and its europium complexes has been synthesized and confirmed by IR,TG-DSC,elemental analysis and con- tinuous molar ratio method. The ligands and its rare earth picrate had formed a 1：1 complex（ Eu（pic） 3 L）. The interacting charac- teristics of the rare earth picrate complexes with BSA have also been investigated by UV-visible spectra, fluorescent spectra and cyclic vohammetry. The experimental results show that the rare earth picrate complexes with BSA have formed a kind of 1 ： 1 non- fluorescent complexes Eu（pic） 3 L-BSA. The fluorescence quenching method is static quenching,and there is one binding site be- tween the complexes and the BSA in which the force is hydrogen bonds and van der Waals forces.

关 键 词：含膦三足体 稀土 苦味酸配合物 BSA 

分 类 号：O614.3[理学—无机化学]