稳定同位素标记氨基甲酸乙酯-D_5的合成  

Synthesis of Stable Isotope Labeled Ethyl Carbamate-D_5

作　　者：吕靖[1] 杨维成[1] 李美华[1] 杨超[1] 潘洁[1] 盛立彦 罗勇[1] 

机构地区：[1]上海化工研究院上海稳定同位素工程技术研究中心,上海200062

出　　处：《化学试剂》2015年第6期561-563,共3页Chemical Reagents

基　　金：科技部转制院所专项资助项目(2013EG116256);科技部十二五重点支撑计划资助项目(2012BAK25B03-15)

摘　　要：以C2D5OD为原料,在催化剂作用下与氰酸钠一步反应得到标题化合物,以消耗的C2D5OD计算,收率55.3%。目标产物经气相色谱(GC)、质谱(MS)、核磁(NMR)等分析方法确证,化学纯度≥99.0%,同位素丰度≥99.0 atom%D,可以作为食品安全领域检测用同位素内标试剂。This work shows the efficient synthesis of ethyl carbamate-Ds with C2D5OD as the precursor. The target product was successfully obtained from ethanol-D5 and sodium cyanate in the presence of the acid catalyst. The total yield was 55.3% based on C2D5OD consumed. The chemical purity is 99.0% and deuterium isotopic enrichment is 99.0 atom% D. The compound could be used as internal standard in the food safety field.

关 键 词：氨基甲酸乙酯 同位素标记 合成 

分 类 号：O625.63[理学—有机化学]