hTERT表观调控及其与肿瘤相关性研究  

A review of hTERT epigenetic regulation and the relationship with tumor

作　　者：曹汀明 周滔[1] 倪娟[1] 曹能[1] 汪旭[1] 

机构地区：[1]云南师范大学生命科学学院生物能源持续开发与利用教育部工程研究中心,昆明650500

出　　处：《国际遗传学杂志》2015年第3期152-155,共4页International Journal of Genetics

基　　金：国家自然科学基金（31260268）

摘　　要：hTERT基因编码人端粒酶催化亚基，该亚基以端粒酶RNA为模板反转录形成TYAGGG短串联重复，这些重复序列添加于染色体端粒DNA3’端以维护染色体稳定性。hTERT的转录受多种因素的影响，如以DNA甲基化为代表的表观遗传途径和多种转录因子的调控。hTERT表观异常修饰可能与肿瘤发生相关，探讨hTERT启动子甲基化改变有望为细胞衰老、死亡的调控以及肿瘤诊断提供重要的生物学指标。该文就hTERT不同层次的表观遗传调控改变及其与肿瘤的相关性进行概述。hTERT encodes the catalytic subunit of human telomerase, which adds DNA sequence repeats （TYAGGG） to the 3＇ end of DNA strands in the telomere regions to maintain chromosomal stability. hTERT is regulated by multiple factors, such as the epigenetic regulation represented by DNA methylation and transcriptional requlation by transcription factors. Abnormal hTERT epigenetic modification is likely associated with cell aging, death and tumorigenesis. Evaluation of the methylation of hTERT promoter should provide important biomarkers for the tumor diagnosis. This review makes a brief overview of epige- netic regulation of hTERT at different levels and its the association with tumorigenesis.

关 键 词：HTERT 表观遗传 DNA甲基化 

分 类 号：R730.2[医药卫生—肿瘤]