浸润性乳腺Paget病3例并文献复习  

3 cases report of invasive mammary Paget disease and literature review

作　　者：李晶[1] 谭小军[2] 周文波[1] 梁小曼[1] 

机构地区：[1]广州金域医学检验中心有限公司病理科,广州510330 [2]广州医科大学附属肿瘤医院病理科,广州510095

出　　处：《临床与病理杂志》2015年第5期731-734,共4页Journal of Clinical and Pathological Research

摘　　要：目的：探讨浸润性乳腺Paget病（invasive mammary Paget disease，invMPD）的临床病理特征。方法：回顾性分析3例浸润性乳腺Paget病的临床资料和病理资料并复习文献。结果：3例患者均有乳头糜烂，1例伴有乳头溃疡，1例同侧乳腺左侧外上象限浸润性癌，1例伴有同侧乳腺高级别导管内癌。组织学表现为具有典型的乳腺Paget病的特征，可见小的浸润灶突破基底膜，浸润真皮浅层。免疫组织化学示肿瘤细胞均表达ER、CK7、EMA；2例表达PR，2例HER-2（3＋），1例HER-2（2＋），Ki67从40%~60%；S-100、P63均阴性。结论：浸润性乳腺Paget病是一种罕见的肿瘤，与非浸润性乳腺Paget病（non-invasive mammary Paget disease，non-invMPD）有相似的预后。Objective：To study the clinicopathologic characteristics of invasive mammary Paget disease. Methods：Retrospective analysis of the clinicopathologic data of 3 cases of invasive mammary Paget disease and review literature. Results：A total of 3 cases displayed papillary erosion, 1 case with ulcer, 1 case with invasive carcinoma and 1 case with DCIS. Microscopically, 3 cases displayed typical characteristics of Paget disease, accompanied dermal invasion. Immunohistochemical study showed CK7, EMA, ER were positive in 2 cases, HER-2, PR was positive in 2 case and S-100, P63 were negative in all. Conclusion：Invasive mammary Paget disease is a rare neoplasm and the similar prognosis with non-invasive mammary Paget disease.

关 键 词：乳腺PAGET病 浸润性Paget病 真皮浸润 

分 类 号：R737.9[医药卫生—肿瘤]