进展性脑梗死外周血炎症免疫因子mRNA表达的临床研究  

Clinical Study of Inflammatory Immune Factors mRNA Expression in Patients with Progressive Cerebral Infarction

作　　者：孙志华[1] 贺婕[1] 黄淮[1] 

机构地区：[1]中国石油天然气集团公司中心医院,河北廊坊065000

出　　处：《中西医结合心脑血管病杂志》2015年第5期583-584,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨急性进展性脑梗死与炎症免疫因子基因表达的关系。方法对38例进展性脑梗死、90例非进展性脑梗死患者进行白介素-6(IL-6)、白介素-1 0(IL-1 0)、肿瘤坏死因子-α(TNF-α)mRNA表达测定。结果进展性脑梗死组IL-6、IL-10mRNA表达水平明显异常于非进展性脑梗死组(P<0.05)。IL-6mRNA表达水平是脑梗死进展的危险因素。结论外周血炎症免疫因子基因表达水平的异常与进展性脑卒中密切相关,可能参与进展性脑梗死的发病过程中。Objective To investigate the relationship of progressive cerebral infarction（PCI）with serum inflammatory immune factors gene expression.Methods Thirty-eight patients with PCI and 90 patients with stabile cerebral infarction were enrolled.The levels of interleukin（IL）-6,IL-10,tumor necrosis factor-α（TNF-α）gene expression were measured.Results The levels of IL-6,IL-10 mRNA expression had more significant difference in patients with PCI than that in stabile cerebral infarction.Gene expression of IL-10 was the risk factor in PCI.Conclusion The abnormal levels of inflammatory immune factors mRNA expression may be closely related to PCI.They may play an important role in progressive ischemic stroke.

关 键 词：进展性脑梗死 白介素-6 白介素-10 肿瘤坏死因子-Α 基因表达 

分 类 号：R743.3[医药卫生—神经病学与精神病学]