胃泌素释放肽前体对小细胞肺癌诊断和预后的临床意义  

Diagnostic value and prognosis assessment of pro gastrin-releasing peptide for small cell lung cancer

作　　者：程真珍[1] 冶薇[1] 封敏[1] 

机构地区：[1]新疆医科大学附属肿瘤医院检验科,乌鲁木齐830011

出　　处：《检验医学与临床》2015年第11期1499-1500,1503,共3页Laboratory Medicine and Clinic

基　　金：新疆医科大学科研创新基金(XJC201278)

摘　　要：目的探讨血清胃泌素释放肽前体(Pro-GRP)水平对小细胞肺癌(SCLC)诊断和预后判断的临床价值。方法采用电化学发光法检测120例SCLC、505例非小细胞肺癌(NSCLC)、30例肺部良性疾病患者和150例健康体检者的Pro-GRP和神经元特异性烯醇化酶(NSE)血清学水平,分析Pro-GRP与SCLC复发、转移及预后的关系。结果 SCLC患者血清Pro-GRP、NSE水平均高于健康体检者、肺部良性疾病患者及NSCLC患者,差异有统计学意义(P<0.05);联合检测Pro-GRP和NSE的灵敏度和特异度较高,且Pro-GRP在SCLC的诊断中比NSE更具有灵敏性和特异性;在复发、转移的SCLC患者中,Pro-GRP在复发前30d就已升高,且其水平高于参考值范围5倍的患者更易发生复发转移,差异有统计学意义(P<0.05)。结论 Pro-GRP是较NSE更为特异、敏感的SCLC肿瘤标志物,具有重要的临床意义。[Abstract] Objective The purpose of this study was to discuss the clinical significance of serum levels of Pro- gastrin-releasing peptide（Pro-GRP）in diagnosis and prognosis in patients with small cell lung cancer（SCLC）. Meth- ods The serum levels of Pro-GRP and NSE of 120 SCLC patients,505 NSCLC patients,30 lung benign disease pa- tients and 150 healthy were compared, and analyze for their diagnostic sensitivity and specificity,and The serum levels of Pro-GRP correlation with relapse and prognosis. Results The serum levels of Pro-GRP and NSE in SCLC were higher than that of NSCLC,lung benign disease and healthy（P^0.05）~The high Sensitivity and specifiq!~y of the Pro-GRP and NSE was combined detection, the Sensitivity and specificity of the Pro-GRP higher than NSE~ In pa- tients with relapsed or metastasis SCLC,the Pro-GRP was increased before SCLC relapsed 30 days^The serum levels of Pro-GRP 5 times higher than normal in SCLC is easier relapsed and metastasis（P^0.05）. Conclusion Pro-GRP is a more specific and sensitive marker than NSE for the diagnosis of SCLC,which could reflect the therapeutic effect and monitor relapse.

关 键 词：小细胞肺癌 胃泌素释放肽前体 诊断和预后 临床评价 

分 类 号：R734.2[医药卫生—肿瘤]