乳腺癌患者血清可溶性细胞膜糖蛋白水平检测的意义  

Detection of serum soluble Endoglin level in patients with breast cancer

作　　者：李琛[1] 李璐[2] 蔡良真[3] 

机构地区：[1]广东医学院附属医院检验科,广东湛江524001 [2]广东医学院组织学与胚胎学教研室,广东湛江524001 [3]广东医学院附属医院肿瘤科,广东湛江524001

出　　处：《检验医学与临床》2015年第11期1565-1566,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨乳腺癌患者血清可溶性细胞膜糖蛋白(Endoglin)水平测定的临床意义。方法采用酶联免疫吸附试验(ELISA)检测35例健康女性、70例乳腺癌患者的血清可溶性Endoglin水平,并比较48例乳腺癌患者手术前后血清可溶性Endoglin水平。结果乳腺癌患者血清可溶性Endoglin水平明显高于健康对照者,差异有统计学意义(P<0.01);血清可溶性Endoglin水平与患者临床分期相关,与患者年龄、病理类型无关;Ⅳ期乳腺癌患者血清可溶性Endoglin水平明显高于其他各期,差异有统计学意义(P<0.01或P<0.05),Ⅲ期高于Ⅱ期,差异有统计学意义(P<0.01),Ⅱ期高于Ⅰ期,差异有统计学意义(P<0.05);乳腺癌患者术后血清可溶性Endoglin水平明显低于术前,差异有统计学意义(P<0.01)。结论动态检测可溶性Endoglin水平对乳腺癌的诊断和临床分期具有重要意义。Objective To investigate the level of serum soluble Endoglin in patients with breast cancer before and after operation and its clinical value. Methods The level of serum soluble endoglin was measured by Enzyme linked immunosorbent assay （ELISA） in 35 healthy women and 70 breast cancer patients,and 48 patients with breast cancer before and after operation as well. Results Level of serum Endoglin were higher in breast cancer patients compared to the healthy controls （P〈0.01）. Serum soluble Endoglin level was correlated with clinical stage,but not with age and pathologic subtypes. The serum Endoglin level in stage IV patients was higher compared with stage Ⅲ, Ⅱ and Ⅰ （P〈0.01 or P〈0.05）,in stage Ⅲ it was higher than in stage Ⅱ （P〈0.01）, and in stage Ⅱ it was higher than in stage Ⅰ（P〈0.05）. The level of serum Endoglin was obviously reduced in patients with breast cancer after operation（P〈0.01）. Conclusion The results suggest that measurement of serum soluble Endoglin may be of great value in aided diagnosis and evaluation of disease of breast cancer.

关 键 词：可溶性细胞膜糖蛋白 乳腺癌 手术 

分 类 号：R735.9[医药卫生—肿瘤]