妊娠高血压患者血清淀粉样蛋白A、血浆内皮素1和一氧化氮水平变化及其相互关系  

Significance of serum amyloid A,endothelin-1 and nitric oxide in patients with pregnancy-induced hypertension

作　　者：李峻[1] 王小娟[1] 

机构地区：[1]上海市浦东新区公利医院妇产科,上海200135

出　　处：《临床荟萃》2015年第6期621-624,共4页Clinical Focus

摘　　要：目的探讨妊娠高血压患者血清淀粉样蛋白A(SAA)、血浆内皮素1(ET-1)和一氧化氮(NO)水平变化及其相互关系。方法选择妊娠高血压患者65例,按照疾病严重程度分为单纯妊娠高血压24例,子痫前期轻度19例和子痫前期重度22例。健康孕妇30例和健康体检的妇女20例分别为正常妊娠组和健康对照组。检测各组SAA,ET-1和NO水平,分析妊娠高血压患者SAA,ET-1和NO水平与疾病严重程度之间的相关性。结果 1与健康对照组比较,妊娠高血压组和正常妊娠组的SAA和ET-1水平明显增高,妊娠高血压组明显高于正常妊娠组(P<0.01);妊娠高血压组和正常妊娠组NO水平明显降低,妊娠高血压组明显低于正常妊娠组(P<0.01)。2与单纯妊娠高血压组比较,子痫前期轻度和子痫前期重度组的SAA和ET-1水平明显增高,子痫前期重度组高于子痫前期轻度组(P<0.01);子痫前期轻度和子痫前期重度组NO水平明显降低,子痫前期重度组低于子痫前期轻度组(P<0.05)。3妊娠高血压患者的SAA水平与ET-1水平呈正相关(r=0.876,P<0.05),而与NO水平呈负相关(r=-0.761,P<0.05)。结论妊娠高血压患者存在内皮细胞功能紊乱,SAA,ET-1和NO参与了妊娠高血压的发生发展,测定SAA,ET-1和NO水平有助于妊娠高血压的早期诊断。Objective To observe the significance of serum amyloid A （SAA）,endothelin-1 （ET-1）and nitric oxide （NO）in patients with pregnancy-induced hypertension and their relationship.Methods A total of 65 patients with pregnancy-induced hypertension were selected as pregnancy-induced hypertension group,including 24 cases with solely pregnancy-induced hypertension, 1 9 cases with mild preeclampsia and 22 cases with severe preeclampsia according to disease severity.At the same period,30 healthy pregnant women and 20 healthy women were selected as normal pregnancy control group and healthy control group,respectively.The levels of SAA,ET-1 and NO in pregnancy-induced hypertension group,normal pregnancy group and healthy control group were detected and their relationship with disease severity was observed.Results ① The levels of SAA and ET-1 in pregnancy-induced hypertension group and normal pregnancy group were significantly higher than those of healthy control group,and the levels of SAA and ET-1 were significantly higher in pregnancy-induced hypertension group than in normal pregnancy group （P 〈0.01）;while the level of NO was significantly decreased,and the level of NO was significantly decreased in pregnancy-induced hypertension group than in normal pregnancy group （P 〈0.01）.②The levels of SAA and ET-1 in severe preeclampsia and mild preeclampsia group were significantly higher than in pregnancy-induced hypertension group,and the indexes in severe preeclampsia group were significantly higher than those of mild preeclampsia group;while NO level was significantly decreased,and NO level was significantly decreased in severe preeclampsia group than in mild preeclampsia group （P 〈 0.05 ）.③ The SAA level in patients with pregnancy-induced hypertension was positively correlated with ET-1 （r =0.876,P 〈0.05）,while the SAA level was negatively correlated with NO （r =-0.761,P 〈0.05）.Conclusion Endothelial dysfunction is found in pregnancy-induced hypertension,the markers of SAA,ET-1 and

关 键 词：高血压 妊娠性 先兆子痫 血清淀粉样蛋白A 一氧化氮 内皮素1 

分 类 号：R741.246[医药卫生—神经病学与精神病学]