依达拉奉在急性脑梗死和脑出血患者中的疗效观察  

Effect of edaravone combined drug usage in patients with cerebral infarction and cerebral hemorrhage

作　　者：齐发梅[1] 袁秀梅[1] 周爱花[1] 王爱霞[1] 贾彦娟[1] 

机构地区：[1]甘肃省人民医院,甘肃兰州730000

出　　处：《国际检验医学杂志》2015年第11期1511-1512,共2页International Journal of Laboratory Medicine

基　　金：2012年甘肃省卫生行业科研计划项目(GSWST2012-18)

摘　　要：目的评估依达拉奉在治疗急性脑梗死和脑出血疾病中的疗效。方法急性脑梗死患者251例,脑出血患者204例及体检健康者485例为研究对象,455例脑梗死及脑出血患者分为普通用药组和依达拉奉联合普通用药组,比较2组患者在治疗不同时期血清超氧化物歧化酶(SOD)和同型半胱氨酸(Hcy)水平变化,以及患者出院时的恢复情况及转归。结果依达拉奉联合普通用药组与普通用药组治疗7d后血清SOD水平明显高于普通用药组,而Hcy水平低于普通用药组,差异均有统计学意义(P<0.05);依达拉奉联合普通用药组恢复良好的患者比率明显高于普通用药组,差异有统计学意义(χ2=7.962,P=0.005)。结论依达拉奉与普通溶栓或止血药联合应用可以有效提高治疗效果,延缓病情发展,降低致残率、致死率,提高患者的生活质量。Objective To evaluate the effect of edaravone combined drug usage in patients with cerebral infarction and cerebral hemorrhage .Methods A total of 251 patients with cerebral infarction ,204 patients with cerebral hemorrhage and 485 healthy peo‐ple were selected in this study ,455 patients with cerebral infarction and cerebral hemorrhage were divided into edaravone combined drug usage group and common drug usage group .The levels of serum superoxide dismutase （SOD）and homocysteine（Hcy） ,the prognosis status of patients in the two groups at different time were compared .Results The mean serum level of SOD were higher in the edaravone combined drug usage group than those in common drug usage group （P〈 0 .05） .The ratio of recovery well were higher in the edaravone combined drug usage group than that in common drug usage group（χ2 = 7 .962 ,P = 0 .005） .Conclusion The treatment that edaravone combined common drug could improve the level of serum SOD ,reduce Hcy ,and enhance the therapeu‐tic effects of cerebral infarction and cerebral hemorrhage patients .

关 键 词：急性脑梗死 急性脑出血 依达拉奉 超氧化物歧化酶 同型半胱氨酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]