干细胞在肝脏疾病治疗中的临床应用及分子机制  

Clinical application and molecular mechanisms of stem cell therapy for liver disease

作　　者：周霞[1] 韩英[1] 

机构地区：[1]第四军医大学西京医院消化病医院,西安71003

出　　处：《中华细胞与干细胞杂志（电子版）》2015年第2期58-65,共8页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：干细胞是指一群具有自我更新和多向分化潜能的细胞,是最有治疗潜力的细胞资源,已成为再生医学领域的研究热点。目前,已有多种干细胞用于肝脏疾病的治疗,能有效改善患者血清指标,减少并发症发生,并提高生活质量。这些干细胞在细胞来源、移植途径及治疗效果等多个方面各有特点,但其治疗肝脏疾病的机制尚不清楚。本文将对目前已用于肝病治疗的各种干细胞的临床应用以及可能的分子机制进展进行阐述。Stem cells （SCs） are cells that can renew themselves and transform into the specialized cell types of tissues or organs, including hepatocyte-like cells. They provide promising potential therapy for patients with liver disease, including the improvement of serum parameters, the recovery of hepatic function, and even the improvement of quality of life, with few adverse effects. Recently, different stem cells have been used for liver disease therapy. These stem cells differ in cell sources, transplantation routes, and treatment effects. Moreover, the mechanisms of stem cell therapy for liver diseases are still not clear. Thus, we will review the clinical application and molecular mechanisms of stem cell therapy, in order to figure out the optimal treatment for liver diseases.

关 键 词：干细胞 肝病 临床医学 分子机制 

分 类 号：R575[医药卫生—消化系统]