氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病的疗效观察  

Clinical observation on fludarabine combined with cyclophosphamide in chronic lymphocytic leukemia

作　　者：汤如[1] 杨泰[1] 吴燕明[1] 

机构地区：[1]安徽医科大学附属巢湖医院,安徽巢湖238000

出　　处：《临床医药实践》2015年第6期414-416,共3页Proceeding of Clinical Medicine

摘　　要：目的:观察氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病(CLL)的疗效和安全性。方法:将CLL患者40例随机分为治疗组和对照组,各20例。治疗组予以氟达拉滨联合环磷酰胺方案治疗,对照组予以CHOP方案化疗,比较两组总有效率及不良反应。结果:治疗组总有效率为90.00%,高于对照组的60.00%,两组比较差异有统计学意义(P<0.05);两组胃肠道反应、感染及骨髓抑制发生率比较,差异无统计学意义(P>0.05)。结论:氟达拉滨联合环磷酰胺组治疗CLL具有完全缓解率及总有效率高、不良反应轻等优点。Objective：To observe the efficacy and safety of fludarabine combined with cyclophosphamide in chronic lym-phocytic leukemia（ CLL）. Methods：Forty cases of patients diagnosed CLL were randomly divided into treatment group and con-trol group,each of 20 cases. Treatment group was given fludarabine combined with cyclophosphamide. Control group was treated with CHOP regimen. To compare the total efficiency rate and adverse reactions of two groups. Results：The total effective rate of teatment group（ 9 0 . 0 0%）was higher than that of control group（ 6 0 . 0 0% ）,the difference was statistically significant（ P 〈0. 05）. There was no statistical difference（P〉0. 05）between two groups in rates of gastrointestinal tract reaction,infection and the incidence of bone marrow suppression. Conclusion：Fludarabine combined with cyclophosphamide in CLL has a much better effect and less toxic side effect.

关 键 词：氟达拉滨 环磷酰胺 慢性淋巴细胞白血病 

分 类 号：R733.7[医药卫生—肿瘤]