奥氮平与氯氮平治疗青春型精神分裂症的对照研究  

Comparison of Curative Effect and Safety of Olanzapine and Clozapine in the Treatment of Female Schizophrenia

作　　者：杨建华 

机构地区：[1]哈尔滨市普宁医院,黑龙江哈尔滨150027

出　　处：《中外医疗》2015年第10期125-127,共3页China & Foreign Medical Treatment

摘　　要：目的对比奥氮平与氯氮平对青春型精神分裂症的疗效及不良反应。方法采用随机分组法将符合青春型精神分裂症诊断标准的患者分为两组,分别采取奥氮平和氯氮平进行治疗,疗程8周。疗效判定依据阳性症状和阴性症状量表(PANSS)和临床疗效总配电量表(CGI)、不良反应评定依据精神药物副反应量表(TESS)。结果经过8周治疗,所有患者PANSS、CGI评分均显著降低,差异有统计学意义(<0.01)。组间比较PANSS、CGI评分,差异无统计学意义(>0.05),奥氮平组不良反应发生率低于氯氮平组,差异有统计学意义。结论奥氮平与氯氮平对青春型精神分裂症的疗效相当,奥氮平的副作用较氯氮平少,更适用有青春型精神分裂症患者。Obuective To compare the curative effect and safety of the therapy scheme to apply olanzapine and clozapine th the female schizophrenia. Methods 67 female patients with schizophrenia by CCMD-3 were randomly allocated to two groups treated with quetiapine or risperedone for 8 weet .We evaluate the result by the Positive and Negative Syndrome Scale for schizophrenia （PAN-SS） the Clinical Global Impression Scale（CGI）,the Treatemnt Symptom Scale（TESS）.Results By the end of the 8 weeks, the PANSS and CGIscores of two groups decreased notably （ 〈0.01）. There was no significant difference between the two groups（ ＆gt;0.05）.Incidence fo adverse effects in the quetiapine group was lower than that in the risperidone group ,but the differ-encewas not significant （ ＆gt;0.05） . Conclusions The results suggest that quetianpin is as effective as risperidone for the treatment of female schizophrenia,The rates of extra-pyramidal symptoms and en-docrime change were higher in the risperidone group than those in the quetiapin group. Olanzapine is beneficial for female schizophre-nia.

关 键 词：青春型精神分裂症 奥氮平 氯氮平 疗效 不良反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学]