HMGB1与结肠癌的相关性及其致癌机制  

The Correlation between HMGB1 and Colorectal Cancer and the Carciogenic Mechanism

作　　者：章文佳[1] 夏敏[1] 

机构地区：[1]南京医科大学附属无锡市人民医院消化内科,江苏无锡214023

出　　处：《医学综述》2015年第10期1771-1773,共3页Medical Recapitulate

摘　　要：高迁移率族蛋白1(HMGB1)是近年来肿瘤研究的热点,HMGB1是非组蛋白染色体蛋白,在血管生成、抗原呈递、细胞自噬等方面参与肿瘤的发生、发展和转移。HMGB1在结肠癌患者中高表达,血清HMGB1水平随疾病进展而明显增高,结肠癌伴肝转移患者的原发灶和转移灶均呈高表达,Dukes D期门静脉中HMGB1水平高于Dukes C期。HMGB1在细胞内的表达部位与T淋巴细胞的浸润相关,后者可影响患者的5年生存率。因此,HMGB1可作为评估结肠癌病情发展及预后的指标。High-motility group box-1 （ HMGB1 ） is the focus of recent cancer research.HMGB1 is a non-histone chromosomal protein,which plays a critical role in cancer development,progression,and metasta-sis by enhancement of tumor angiogenesis,presenting antigen,and autophagy.Higher HMGB1 concentrations are found in the patients with colon cancer.Serum HMGB1 levels are significantly increased along the dis-ease progression.In patients of colon cancer with hepatocellular metastasis,HMGB1 is highly expressed in both the primary and metastasis foci,and the portal blood HMGB1 concentration is higher in Dukes D cases than in Dukes C cases.The expression position of HMGB1 is associated with lymphocyte infiltration ,which may affect the 5-year survival rate.Therefore,HMGB1 can be used as an index to assess the progression and prognosis of colorectal cancer.

关 键 词：结肠癌 高迁移率族蛋白B1 肿瘤 

分 类 号：R735.35[医药卫生—肿瘤]