2011-2013年广东省预防接种后发生急性播散性脑脊髓炎的风险评估  

Risk assessment for the occurrence of acute disseminated encephalomyelitis after vaccination during 2011-2013 in Guangdong province

作　　者：张吉凯 黄竹航 谢莘[2] 郑慧贞[2] 瞿红鹰 赵占杰[2] 刘宇[2] 

机构地区：[1]广东省生物制品与药物研究所,广州510300 [2]广东省疾病预防控制中心免疫所,广州511430

出　　处：《广东医学》2015年第9期1418-1420,共3页Guangdong Medical Journal

基　　金：广东省医学科研基金立项课题(编号:A2012087)

摘　　要：目的评估预防接种后发生急性播散性脑脊髓炎（ADEM）的风险。方法以2011—2013年各类疫苗的接种人次数作为观察例数,以2008—2010年广东省ADEM流行病学调查获得的年龄组发病率作为发生概率,采用Poisson分布的单侧累计概率函数,计算预防接种后ADEM发病的Poisson分布的单侧累计概率,评估2011—2013年全省预防接种后发生ADEM的风险。结果 2011—2013年全省人群不同疫苗预防接种后ADEM发病8例;各年度各类疫苗接种后ADEM发病单侧累计概率在0.684 9～0.999 3之间。结论 2011—2013年预防接种后的人群ADEM发病率与一般人群比较差异无统计学意义,预防接种未增加ADEM的发病风险。Objective To assess the risk of the acute disseminated encephalomyelitis（ ADEM） after vaccination.Methods Based on the vaccinated population from 2011 to 2013,the incidences of ADEM among different age groups from 2008 to 2010 obtained from epidemiological investigation in Guangdong province were taken as control,one- tailed cumulative probability of Poisson distribution was calculated to assess the risk of ADEM after vaccination in Guangdong Province during 2011- 2013. Results There were eight ADEM cases among vaccination population in Guangdong Province during 2011- 2013. The one- tailed cumulative probability of the occurrence of ADEM after vaccination each year varied from 0. 684 9 to 0. 999 3. Conclusion There is no statistically significant difference in ADEM incidence between those who received vaccination and the general population from 2011 to 2013 in Guangdong Province,suggesting vaccination doesn＇t increase the risk of ADEM.

关 键 词：急性播散性脑脊髓炎 预防接种 风险评估 

分 类 号：R744.53[医药卫生—神经病学与精神病学]