AMC及ALC与侵袭性B细胞淋巴瘤低危患者的预后关系分析  

Relationship between absolute monocyte/lymphocyte count and prognosis in low-risk patients with aggressive B cell lymphoma

作　　者：徐诣芝[1] 何代英[1] 罗治彬[1] 李静[1] 王琛[1] 

机构地区：[1]重庆市第三人民医院肿瘤血液科,400014

出　　处：《重庆医学》2015年第16期2212-2213,2216,共3页Chongqing medicine

基　　金：重庆市卫生局面上项目(2012-2-221)

摘　　要：目的 探讨外周血单核细胞绝对计数（AMC）及淋巴细胞绝对计数（ALC）与侵袭性B细胞淋巴瘤低危患者预后的相关性。方法 回顾性分析了2003~2013年42例初发侵袭性B细胞淋巴瘤低危患者的AMC、ALC及淋巴细胞/单核细胞比值（LMR）与患者各项临床指标、无进展生存期（PFS）和总生存期（OS）的相关性。结果 据ROC曲线划分AMC、ALC、LMR对5年OS影响的界限值分别为475/mm^3、1 005/mm^3和2.1。AMC≥475/mm^3、ALC〈1 005/mm^3是PFS的独立不良因素（RR=4.271、3.023;P=0.01、0.39）;AMC≥475/mm^3是OS的独立不良因素（RR=4.680;P〈0.01）。结论 初发时高AMC、低ALC患者预后较差。推测外周血AMC、ALC可能成为侵袭性B细胞淋巴瘤低危患者进一步分层的预后指标。Objective To investigate the prognostic significance of peripheral blood absolute monocyte/lymphocyte count in low-risk patients with aggressive B cell lymphoma. Methods Retrospective study was performed in 42 low-risk patients with aggressive B cell lymphoma approved by histology between 2003 to 2013. Peripheral blood absolute monocyte count （AMC）, absolute lymphocyte count （ALC） ,lymphocyte/monocyte（LMR） and the some other clinical characters were estimated. Results The best absolute monocyte/lymphocyte count cut-offs respectively were 475/mm^3 and 1 005/mm^3 ,analyzed by receiver operating character- istic curve. AMC≥475/mm^3 and ALC〈1 005/mma were found to be independent predictors of progress free survival （RR=4. 271, 3. 023;P= 0.01,0.39） ;AMC≥475/mm^3 was found to be independent predictors of 5-year overall survival （RR = 4. 680;P〈 0. 0001） in low-risk patients with aggressive B cell lymphoma. Conclusion Higher AMC and/or lower ALC are poor prognosis factors. AMC and ALC may be important prognostic factors of low-risk patients with aggressive B cell lymphoma.

关 键 词：单核细胞 淋巴细胞 淋巴瘤 B细胞 低危 预后 

分 类 号：R733.1[医药卫生—肿瘤]