高原地区动脉粥样硬化性脑梗死患者高敏C反应蛋白的动态变化  

Dynamic changes of hs-CRP in patients with atherosclerotic ischemic stroke at high altitude

作　　者：王兰桂[1] 杨春丽[1] 马香莲[1] 黄茜[1] 马丽萍[1] 杨占银 

机构地区：[1]青海大学附属医院神经内科,西宁810001 [2]海南藏族自治州人民医院神经内科

出　　处：《中华老年心脑血管病杂志》2015年第6期616-618,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：青海大学附属医院中青年科研基金项目(ASRF-2009-01)

摘　　要：目的探讨高原地区急性动脉粥样硬化性脑梗死患者血浆高敏C反应蛋白(hs-CRP)的动态变化。方法收集世居西宁地区(海拔约2200m)58例和海南藏族自治州(海拔约3000m)55例的动脉粥样硬化性脑梗死汉族患者分别作为病例1组和病例2组;同期收集上述两地体检中心健康体检汉族各60例作为对照1组和对照2组;采用散射比浊法测定病例1、2组24h内、72h、1周和1个月血浆hs-CRP水平。结果病例1组24h内、72h、1周和1个月血浆hs-CRP高于对照1组[(4.46±1.95)mg/L、(8.87±2.01)mg/L、(5.45±1.13)mg/L和(3.84±0.82)mg/Lvs(1.89±0.92)mg/L,P<0.05];病例2组上述各时间点hs-CRP高于对照2组[(6.68±1.43)mg/L、(11.14±2.12)mg/L、(7.49±1.21)mg/L和(6.33±1.12)mg/L vs(2.02±0.96)mg/L,P<0.05]。病例2组不同时间血浆hs-CRP高于病例1组,差异有统计学意义(P<0.05)。结论在高原缺氧环境下,hs-CRP水平增加,可能导致脑梗死继发脑损害加重。Objective To study the dynamic changes of hs-CRP in patients with atherosclerotic ischemic stroke at high altitude.Methods Fifty-eight patients with atherosclerotic ischemic stroke from Xining district（about 2200mheight）served as patient group A,55 Han nationality patients with atherosclerotic ischemic stroke from Hainan Tibetan Autonomous Prefecture（about 3000 m height）served as patient group B,60 Han nationality volunteers from Xining district served as control group A and 60 Han nationality volunteers from Hainan Tibetan Autonomous Prefecture served as control group B.Their serum hs-CRP levels were measured by nephelometry.ResultsThe serum hs-CRP levels were significantly higher in patient groups A and B than in control groups A and B（4.46±1.95 mg/L,8.87±2.01 mg/L,5.45±1.13 mg/L and 3.84±0.82mg/L vs 1.89±0.92mg/L,6.68±1.43mg/L,11.14±2.12mg/L,7.49±1.21mg/L and 6.33±1.12mg/L vs 2.02±0.96mg/L,P〈0.05）,and in patient group B than in patient group A（P〈0.05）.Conclusion Inflammatory reaction may play a certain role in acute atherosclerotic ischemic stroke and secondary brain damage at high altitude.The elevated serum hs-CRP level may aggravate secondary brain damage in hypoxic environment at high altitude.

关 键 词：动脉粥样硬化 脑梗死 C反应蛋白质 缺氧 脑 高海拔 

分 类 号：R743.3[医药卫生—神经病学与精神病学]