木质素季铵盐-海藻酸钠聚合物负载阿维菌素粉体的制备及抗紫外光性能分析  

Preparation and UV-shielding Properties of Quaternary Ammonium Salt of Lignin-sodium Alginate Polymer Loading Avermectin

作　　者：卢晶[1] 罗华超[1] 张琼[2] 方桂珍[1] 任世学[1] 

机构地区：[1]东北林业大学材料科学与工程学院,黑龙江哈尔滨150040 [2]中国林业科学研究院林产化学工业研究所,江苏南京210042

出　　处：《生物质化学工程》2015年第3期17-22,共6页Biomass Chemical Engineering

基　　金："十二五"农村领域国家科技计划课题项目(2012BAD24B0403);国家自然科学基金资助项目(31170542)

摘　　要：以三甲基木质素季铵盐-海藻酸钠(QL-SA)为载体,用物理混合法制备了阿维菌素缓释聚合物(AVM-QL-SA),利用FT-IR对其结构进行了表征,探讨了交联剂用量、药物加入量、体系p H值等因素对载药量和包封率的影响,并对其缓释性能和抗紫外光降解进行了研究。结果表明:阿维菌素(AVM)均匀的混合在QL-SA载体中,主要以物理混合为主;最佳制备条件为:戊二醛为5%(以单体质量分数计)、药物加入量为1%(以单体质量分数计)、体系p H值为8.5,载药量和包封率分别达到1.36%和73.36%;阿维菌素缓释聚合物粒径符合正态分布,平均粒径为83.90μm;阿维菌素缓释聚合物具有很好的缓释性能,在乙醇/水(体积比1∶1)中释放30 h,累计释放率为88.97%;经8 h紫外光照射,阿维菌素原药中AVM残留量为6.24%,阿维菌素缓释聚合物中AVM残留量为37.75%,具有良好的抗紫外分解性能。LU Jing;LUO Hua-chao;ZHANG Qiong;FANG Gui-zhen;REN Shi-xue;College of Material Science and Technology,Northeast Forestry University;Institute of Chemical Industry of Forest Products,CAF; Slow-release polymer of avermectin（ AVM-QL-SA） was prepared using trimethyl quaternary ammonium salt of ligninsodium alginate（ QL-SA） as carriers by physical blending. Based on the structure elucidation of slow release-polymer through FTIR,the effects of the factors such as the dosage of crosslink agent and abamectin as well as the p H fluctuation on the drug loading（ DL） and the encapsulation efficieney（ EE） were discussed. The results indicated that the avermectin was mixed with QL-SA uniformly and no chemical reaction happened. The optimal process conditions of AVM-QL-SA were the dosage of glutaraldehyde4%（ solids content）,drug loading of 1%,the p H of reaction system 8. 5（ washing the product with water to neutral）. Under these conditions,the obtained DL and EE were 1. 36% and 73. 36%,respectively and the particle size of AVM-QL-SA accorded with normal distribution with average particle size of 83. 90 μm. AVM-QL-SA had good slow release performance and with the releasing time of 30 h in ethanol / water（ 1 ∶ 1）. The rate of cumulative release was 88. 97% and the residual rate of AVM was 37. 75%.Under UV irradiation for 8 h,the residual rate was 6. 24%. It was confirmed that AVM-QL-SA had the function of resistance against UV.

关 键 词：木质素季铵盐 聚合物 阿维菌素 缓释 

分 类 号：TQ450.68[化学工程—农药化工]