胰腺神经内分泌癌的临床病理特点和预后因素分析  

Pancreatic neuroendocrine carcinoma： clinicopathological characteristics and prognosis

作　　者：辛宝宝[1] 楼文晖[1] 李剑昂[1] 韩序[1] 许雪峰[1] 

机构地区：[1]复旦大学附属中山医院普外科复旦大学普外科研究所,上海200032

出　　处：《中华普通外科杂志》2015年第5期352-356,共5页Chinese Journal of General Surgery

基　　金：卫生公益性行业科研专项经费项目（201202007）

摘　　要：目的 探讨胰腺神经内分泌癌的临床病理特点和影响患者预后的相关因素.方法 回顾性分析复旦大学附属中山医院2000年4月至2013年8月收治的21例胰腺神经内分泌癌患者的临床病理和随访资料,对可能影响患者预后的相关因素进行统计学分析.结果 单因素分析显示,年龄、临床分期、肿瘤大小、肿瘤分化程度及有无淋巴结转移对患者的存活率影响差异均有统计学意义（均P＜0.05）.多因素分析（Cox回归）显示,年龄（P =0.019）是影响患者预后的独立危险因素,年龄＜60岁者,预后较好.结论 胰腺神经内分泌癌患者多为无功能性,大多数无特殊临床表现,易发生远处转移,年龄是影响患者预后的独立危险因素.Objective To analyze the clinicopathological characteristics and the related factors influencing the prognosis of pancreatic neuroendocrine carcinoma.Methods The clinicpathological and follow-up data of 21 patients with pancreatic neuroendocrine carcinoma admitted between April 2000 and August 2013 in Zhongshan Hospital of Fudan University were analyzed retrospectively.The influence facts on patients＇ prognosis were analyzed statistically.Results Univariate analysis showed that age,stage,tumor size,degree of tumor differentiation and lymph node metastasis were factors separately influenced patients＇ survival.Multivariate analysis （Cox regression） revealed that age （P =0.019） was the only independent factor affecting the prognosis.Conclusions Patients with pancreatic neuroendocrine carcinoma were mostly non-functional and presented no specific clinical features.Tumors tended to metastasize and the prognosis was poor.Age was the independent factor affecting the prognosis.

关 键 词：胰腺肿瘤 神经内分泌瘤 预后 肿瘤转移 

分 类 号：R736.7[医药卫生—肿瘤]