重复 TACE 治疗周期对原发性肝癌预后的影响  

Influence of repeated TACE treatment interval on the prognosis of hepatocellular carcinoma

作　　者：张一军[1] 杨业发[1] 申淑群[1] 葛乃建[1] 梁军[1] 伍路[1] 于晓河[1] 石志勇[1] 吴东[2] 吴孟超[1] 

机构地区：[1]第二军医大学东方肝胆外科医院微创介入中心,上海200438 [2]第二军医大学东方肝胆外科医院特需治疗科,上海200438

出　　处：《实用放射学杂志》2015年第5期824-828,共5页Journal of Practical Radiology

摘　　要：目的：探讨经动脉化疗栓塞（TACE）治疗周期对中晚期原发性肝癌预后的影响。方法回顾性收集重复行 TACE 治疗的中晚期原发性肝癌患者123例。这些患者分为定期重复组（A 组）和按需重复组（B 组）。应用 Cox 回归、生存曲线及 log-rank 检验比较不同治疗周期对预后的影响。结果 A 组和 B 组的治疗重复周期分别为（1.1±0.3）月和（3.0±1.5）月（P〈0.001）。多因素 Cox 分析结果提示疗效（P =0.024）和重复周期（P〈0.001）是影响患者预后的独立影响因素。结论重复 TACE 治疗周期是中晚期肝细胞癌患者预后的独立影响因素。按需重复 TACE 治疗可能更有利于患者的预后。Objective To investigate the effects of transarterial chemoembolization （TACE）treatment interval on the prognosis of patients with advanced hepatocellular caisinoma（HCC）.Methods We retrospectively collected clinical data of 123 advanced HCC patients treated with repeated TACE.The patients were divided into two groups （group A with fixed repeated treatment interval and group B with that according to the clinical needs）.Cox regression,survival curve and log-rank test were used to assess the effects of the treat-ment intervals on prognosis.Results The treatment intervals of the group A and group B were （1.1±0.3）months and （3.0±1.5） months,respectively （P〈0.001）.Multivariate Cox analysis showed the efficacy （P =0.024）and repetition periods （P〈0.001 ） were independent prognostic factors.Conclusion TACE interval is independent risk factor for the prognosis of patients with ad-vanced HCC.Repeated TACE treatment according to clinical needs may be more favorable for prognosis of the patients.

关 键 词：原发性肝癌 经动脉化疗栓塞术 重复周期 预后 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]