三阴型乳腺癌中HMGA2高表达及其与乳腺癌转移的相关性  

Overexpression of HMGA2 in triple negative breast cancer and its correlation with lymph node metastasis

作　　者：罗明华[1] 李剑[1] 邵牧民[2] 余光银[1] 尹为华[1] 

机构地区：[1]北京大学深圳医院病理科,深圳518036 [2]广州中医药大学深圳附属医院病理科,深圳518033

出　　处：《临床与实验病理学杂志》2015年第5期560-564,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：深圳市医疗卫生类科研(20130228164)

摘　　要：目的检测高迁移率族蛋白A2(high mobility group A2,HMGA2)在乳腺癌中的表达,分析其与临床病理特征的关系,探讨HMGA2在乳腺癌不同分子亚型中的表达。方法采用免疫组化Eli Vison两步法检测58例乳腺癌中HMGA2蛋白的表达。结果 (1)管腔A、管腔B、HER-2过表达、基底细胞样及未分类型乳腺癌中HMGA2阳性率分别为0、62.5%、60.0%、100.0%及80.0%(三阴型92.3%),差异有显著性(P<0.01)。HMGA2的高表达与三阴型乳腺癌相关(P<0.01)。(2)HMGA2的表达与组织学分级及淋巴结转移相关(P<0.05),与肿瘤大小、患者年龄无关;与Ki-67、CK5/6及EGFR表达呈正相关(P<0.05),与ER及PR表达呈负相关(P<0.01)。结论乳腺癌中HMGA2蛋白的表达与组织学分级、淋巴结转移、Ki-67、CK5/6及EGFR表达呈正相关,与ER、PR表达呈负相关。三阴型分子亚型有更高的HMGA2蛋白表达,HMGA2有望成为三阴型乳腺癌的治疗靶点。Purpose To detect high mobility group protein A2 （HMGA2） expression in breast cancer, and to analyze its relationship with clinicopathological features and the levels of HMGA2 in different molecular subtypes of breast carcinomas. Methods An immu-nohistochemical study was undertaken for measuring the levels of HMGA2 in 58 breast carcinomas. Results （ 1 ） The expression of HMGA2 was 0, 62. 5%, 60. 0%, 100. 0% and 80. 0% in Lum A, Lum B, HER-2-OE, basal-like breast carcinoma （BLBC） and un-classification phenotype respectively （ triple negative breast cancer, 92. 3%） . High expression of HMGA2 was associated with the tri-ple-negative breast cancer （TNBC） subtypes （P〈0. 01）. （2） An association was identified between high expression of HMGA2, and high tumor grade, lymph node metastasis （P〈0. 05）, positive Ki-67, CK5/6 and EGFR （P〈0. 05）, negative ER and PR （P〈0. 01）, but no association was observed for tumor size and patients’age. Conclusion An association is identified between high ex-pression, and high tumor grade, lymph node metastasis, positive Ki-67, EGFR and CK5/6, negative ER and PR, that means a high expression of HMGA2 is associated with an adverse outcome in breast cancer. High expression of HMGA2 are associated with the TNBC subtypes. Thus recognizing HMGA2 as a rational target in TNBC. The results of the study have implications for therapeutic target iden-tification and the design of future clinical trials for TNBC.

关 键 词：乳腺肿瘤 分子分型 HMGA2 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]