肿瘤异常蛋白(TAP)检测在Barrett食管及食管腺癌临床诊断中的意义  

Clinical significance of tumor abnormal protein(TAP) detection in Barrett esophagus and esophageal adenocarcinoma

作　　者：吴永梅[1] 张霁雯[1] 蔡琰[1] 

机构地区：[1]新疆医科大学第五附属医院,830000

出　　处：《现代消化及介入诊疗》2015年第2期83-84,178,共3页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：新疆医科大学第五附属医院自然科学基金(WFY2013002)

摘　　要：目的探讨TAP检测对Barrett食管及食管腺癌的诊断价值和临床意义。方法 75例Barrett食管患者,61例食管腺癌患者,88例正常体检人群,应用双盲法检测末梢血TAP,并计算其灵敏度及特异度。结果 TAP阳性率正常体检人群为12.5%;Barrett食管组为81.33%,食管腺癌组为85.25%,均明显高于正常体检人群,差异有统计学意义(P<0.05)。TAP在Barrett食管筛选中灵敏度为81.33%;对食管腺癌的灵敏度为85.25%。结论 TAP检测可以提高Barrett食管及食管腺癌患者的早期诊断率,对其早诊早治有重要的意义,适用于健康人和高危人群的Barrett食管和食管腺癌筛查。Objective To study and analyze the clinical significance of TAP detection in diagnosis of Barrett＇s esophagus, esophageal adenocarcinoma. Method Peripheral blood TAP was detected in 75 cases of Barrett＇s esophagus, 61 cases of esophageal adenocarcinoma, and 88 cases of healthy subjects by double blind method, and the sensitivity and specificity were calculated. Rusults The positive rate of TAP in normal healthy subjects was 12.5% which was significantly lower than 81.33% in patients with Barrett＇ s esophagus and 85.25% in esophageal carcinoma patients. The sensitivity of TAP in screening the Barrett＇ s esophagus was 81.33%, and 85.25% in esophageal adenocarcinoma. Conclusion TAP detection is helpful in diagnosis of Barrett＇s esophagus and esophageal adenocarcinoma.

关 键 词：肿瘤异常蛋白(TAP) BARRETT食管 食管腺癌 临床诊断 

分 类 号：R571[医药卫生—消化系统]