SCC-Ag在宫颈癌新辅助化疗前后的改变及临床意义  

The clinical significance of SCC-Ag expression before and after neoadjuvant chemotherapy in cervical carcinoma

作　　者：王红霞[1] 丁晓萍[1] 侯庆香[1] 陈玲[1] 靳志涛[2] 

机构地区：[1]中国人民解放军第二炮兵总医院妇产科,北京100088 [2]中国人民解放军第二炮兵总医院医学影像科,北京100088

出　　处：《中国妇产科临床杂志》2015年第3期229-232,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的观察SCC-Ag在宫颈鳞癌新辅助化疗(neo-adjuvant chemtherapy,NACT)前后的表达变化,探讨SCC-Ag与宫颈鳞癌NACT之间的相关性及临床价值。方法采用化学发光法检测NACT宫颈鳞癌患者中不同阶段SCC-Ag的表达水平,探讨SCC-Ag与宫颈鳞癌NACT后患者近期疗效、治疗方案及手术时机选择、临床病理特征及预后的关系。结果宫颈鳞癌患者治疗前血清SCC-Ag水平与临床分期、局部病灶大小和有无淋巴结转移呈正相关,与年龄无关;SCC-Ag表达在NACT后明显降低,临床有效和无效病例中SCC-Ag的表达有差异。结论 SCC-Ag表达水平变化与NACT疗效显著相关,可作为宫颈鳞癌分期、疗效判断、治疗方案及手术时机选择和预后判断的参考指标。Objective To observe the squamous cell carcinoma antigen （SCC- Ag ） expression before and after neo-adjuvant chemotherapy （NACT） in cervical squamous cell carcinoma, and to explore the relationship and significance of SCC- Ag and cervical squamous cell carcinoma. Methods To detect the expression level of SCC - Ag in patients with cervical squamous cell carcinoma at different stages after neo-adjuvant chemotherapy by chemical luminescence method. Results Serum SCC - Ag level in cervical squamous cell carcinoma patients was positively as- sociated with clinical stages, lymph node metastasis but had no relationship with age before treatment. SCC- Ag level decreased significantly after NACT and it was related to the effectiveness of NACT. Conclusion SCC - Ag and NACT curative effect is distinct related, and can be used as a maker for clinical stage, treatment effect, opera- tion time choice and prognosis iudgment.

关 键 词：SCC-AG 宫颈鳞状上皮细胞癌 新辅助化疗 

分 类 号：R737.33[医药卫生—肿瘤]