肝脏枯否细胞研究进展  

Recent advances in kupffer cells

作　　者：孙宏伟[1] 李成林[1] 王平[1] 崔彦[1] 

机构地区：[1]解放军第306医院普通外科,北京100101

出　　处：《中华肝胆外科杂志》2015年第5期351-353,共3页Chinese Journal of Hepatobiliary Surgery

摘　　要：近年来,对肝脏枯否细胞的研究取得了很多进展.在炎症方面,相关研究主要集中于枯否细胞参与、调节炎症反应的具体机制（主要是分子机制）.在脂肪肝方面,人们试图通过揭示枯否细胞在脂肪肝形成过程中所起的重要作用,从而找到防治脂肪肝的新方法.在缺血再灌注损伤方面,许多预处理的新方法就是针对枯否细胞实施的.在肝移植方面,相关研究主要集中于免疫耐受和移植后排斥反应.至于肿瘤,目前研究主要集中在枯否细胞对肿瘤生长、转移的调控机制上.本文将对上述进展做一综述.In recent years,exciting research progress has been made on hepatic Kupffer cells.For inflammation,the study of Kupffer cells focused on its mechanism of whether and how Kupffer cells play a role in regulating inflammatory reaction,especially molecular mechanisms.For fatty liver,researchers are exploring the role of Kupffer cells in the development of fatty liver,as well as potential treatments.For the treatment of ischemia-reperfusion injury,latest protocols were based on Kupffer cells.In the area of liver transplantation,the study of Kupffer cells centered on immune tolerance and graft versus host disease （GVHD）.As for tumor,current studies focused on regulatory mechanism of Kupffer cells on growth and metastasis of tumor.This article will present a review on the latest progress.

关 键 词：肝脏 枯否细胞 研究进展 

分 类 号：R363.21[医药卫生—病理学]