Autologous nerve graft repair of different degrees of sciatic nerve defect:stress and displacement at the anastomosis in a three-dimensional finite element simulation model  

作　　者：Cheng-dong Piao Kun Yang Peng Li Min Luo 

机构地区：[1]Department of Orthopedics,Second Hospital,Jilin University [2]Basic Department,Air Force Aviation University of Chinese PLA [3]Department of Engineering Mechanics,Nanling Campus,Jilin University [4]Department of Pain,China-Japan Union Hospital,Jilin University

出　　处：《Neural Regeneration Research》2015年第5期804-807,共4页中国神经再生研究（英文版）

基　　金：supported by the Science and Technology Development Project of Jilin Province in China,No.20110492

摘　　要：In the repair of peripheral nerve injury using autologous or synthetic nerve grafting, the mag- nitude of tensile forces at the anastomosis affects its response to physiological stress and the ultimate success of the treatment. One-dimensional stretching is commonly used to measure changes in tensile stress and strain; however, the accuracy of this simple method is limited. There- fore, in the present study, we established three-dimensional finite element models of sciatic nerve defects repaired by autologous nerve grafts. Using PRO E 5.0 finite element simulation software, we calculated the maximum stress and displacement of an anastomosis under a 5 N load in 10-, 20-, 30-, 40-mm long autologous nerve grafts. We found that maximum displacement increased with graft length, consistent with specimen force. These findings indicate that three-dimensional finite element simulation is a feasible method for analyzing stress and displacement at the anas- tomosis after autologous nerve grafting.In the repair of peripheral nerve injury using autologous or synthetic nerve grafting, the mag- nitude of tensile forces at the anastomosis affects its response to physiological stress and the ultimate success of the treatment. One-dimensional stretching is commonly used to measure changes in tensile stress and strain; however, the accuracy of this simple method is limited. There- fore, in the present study, we established three-dimensional finite element models of sciatic nerve defects repaired by autologous nerve grafts. Using PRO E 5.0 finite element simulation software, we calculated the maximum stress and displacement of an anastomosis under a 5 N load in 10-, 20-, 30-, 40-mm long autologous nerve grafts. We found that maximum displacement increased with graft length, consistent with specimen force. These findings indicate that three-dimensional finite element simulation is a feasible method for analyzing stress and displacement at the anas- tomosis after autologous nerve grafting.

关 键 词：nerve regeneration sciatic nerve injury autologous nerve grafting epineurial suturing three-dimensional finite element models load stress DISPLACEMENT neural regeneration 

分 类 号：R745[医药卫生—神经病学与精神病学]