微米级磁性介质体外升温检测模型  

The method to test the in vitro heating efficiency of the magnetite microspheres for hyperthermia

作　　者：崔瑞瑞[1] 王晓文[2] 李利亚[3] 何柳[1] 谢柳倩 唐劲天[4] 

机构地区：[1]北京中医药大学中药学院生物制药系,北京100102 [2]清华大学玉泉医院,北京100149 [3]中日友好医院中西医结合肿瘤内科,北京100029 [4]清华大学工程物理系,北京100084

出　　处：《现代肿瘤医学》2015年第11期1482-1488,共7页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81172120;81470308;81372412);国家科技支撑计划项目(编号:2012BAI15B04)

摘　　要：目的:为准确检测介质升温性能,建立用于微米级磁感应热疗介质的检测模型。方法:选取浓度为0.5%、1%、2%、3%的琼脂凝胶及纯水,3种不同的微米级热疗介质分别分散于琼脂凝胶和纯水中。选取不同的测温点,观察磁场下介质的升温情况,比较各分散剂的性能;同时监测各浓度凝胶的凝固时间。选择1%的琼脂凝胶为分散剂,评价不同介质的升温性能和比吸收率(SAR)值。结果:3种浓度凝胶均可与介质形成均匀的混合物,但浓度1%和2%者更优;用浓度为1%琼脂模型,评价了3种微米级磁感应热疗介质的体外升温性能。结论:成功建立了微米级磁感应热疗介质的体外测温模型。Objective：To test the in vitro heating efficiency of magnetite microspheres. Methods：Agar gel with concentrations of 0%,0. 5%,1%,2%,and 3%were prepared. Three different kinds of microspheres were separately dispersed in these dispersant. Then,the samples were placed in an alternating magnetic field. The temperature increase was measured at three separate sites. The concentration of agar gel was chosen by comparing the setting time and the difference of temperature increase at each site. The heating efficiency of the microspheres in 1%agar gel was tested under the magnetic field at different magnetic field frequencies and intensities. The value of the specific absorption rate（ SAR）was calculated. Results：All three kinds of agar gel could be mixed well with these microspheres. The con-centration of 1%and 2%agar gel were satisfied. Conclusion：The method to test the in vitro heating efficiency was successfully established.

关 键 词：体外测温 微米介质 琼脂体模 比吸收率 

分 类 号：R730[医药卫生—肿瘤]