Ese-3在结肠癌组织中的表达及意义  

Expression and clinical significance of Ese- 3 in human colorectal carcinoma

作　　者：聂娜[1] 宋杨[1] 杨静[1] 郑蕾[1] 冯英明[2] 苏海川[1] 

机构地区：[1]第四军医大学附属唐都医院肿瘤科,陕西西安710038 [2]第四军医大学研究生院,陕西西安710032

出　　处：《现代肿瘤医学》2015年第11期1544-1546,共3页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81371176)

摘　　要：目的:探讨上皮转录调控因子-3(epithelium-specific Ets transcription factor-3,Ese-3)在结肠癌组织中的表达及与临床病理特征之间的关系。方法:采用免疫组化SP法检测76例结肠癌组织及癌旁组织标本中Ese-3的表达,分析其表达与患者临床病理特征之间的关系。结果:Ese-3表达于细胞核中。Ese-3蛋白在癌旁正常组织中的表达明显高于相应结肠癌中的表达。在结肠癌组织中Ese-3表达与病理分期(P=0.005)、肿瘤分化程度(P=0.0006)有关,而与患者性别、年龄、肿瘤大小无关(P>0.05)。结论:Ese-3基因表达的缺失或下调可能促进了结肠癌的发生。Objective：To explore the expression of Ese-3 and the relation between Ese-3 expression and clini-cal pathological features in human colorectal cancer. Methods：Using immunohistochemical technique,we detected the expression of Ese-3 in tumor tissue and para-tumor tissue in 76 patients with colorectal cancer. The correlation be-tween Ese-3 expression and clinical pathological features was analyzed. Results：We found that Ese-3 protein was expressed in the nucleus. Ese-3 protein expression in para-tumor tissue was significantly higher than tumor tissue in human colorectal cancer. Expression of Ese-3 was associated with clinical TNM stage and tumor differentiation de-gree（p﹤0. 05）. Conclusion：The reduced expression of Ese-3 in tumor tissues may play an important role in the occurrence and development of human colorectal cancer.

关 键 词：Ese-3 结肠癌 免疫组织化学 

分 类 号：R735.35[医药卫生—肿瘤]