HPIP与胰腺癌的相关性  

Correlation between HPIP and pancreatic cancer

作　　者：王倩[1,2] 陈雄[1,2] 欧阳学农[1,2] 

机构地区：[1]福建中医药大学福州总医院临床医学院 [2]南京军区福州总医院肿瘤内科,福建福州350025

出　　处：《现代肿瘤医学》2015年第11期1610-1613,共4页Journal of Modern Oncology

基　　金：国家自然基金青年基金项目(编号:81302067)

摘　　要：胰腺癌是一种致死率极高的恶性肿瘤,总体五年生存率不及5%。就目前状况而言,胰腺癌的治疗方式有限、效果欠佳、前景堪忧,任何能够改善治疗的探索都是必要的。研究发现,雌激素受体(ER)在胰腺癌中广泛表达;HPIP是一种新型的支架蛋白。近年来相关文献已证实,HPIP与肿瘤细胞的增殖、转移密切相关,有可能成为肿瘤治疗的新靶点。本文就HPIP与胰腺癌的相关性进行初步探讨。Pancreatic carcinoma is one of the cancers with the worst prognosis, it＇s overall 5 -year survival rate is below 5 %, thus any therapeutic improvement is imperative. Hematopoietie Pbx - interaction protein （HPIP）, is a novel scaffolding protein. Up to now, according to the relevant literature, HPIP is closely associated with tumor growth, prolif- eration and metastasis. HPIP may be a new target for cancer therapy in the future. In this paper, we will talk about whether there is a certain relevance between HPIP and pancreatic cancer.

关 键 词：造血相关的PBX相互作用蛋白质基因(HPIP) 雌激素受体(ER) 胰腺癌 

分 类 号：R735.9[医药卫生—肿瘤]