幽门螺杆菌感染与胰腺癌发病相关性的Meta分析  

Helicobacter pylori infection as a risk factor for pancreatic cancer: A Meta analysis

作　　者：王瑞涛[1] 刘军[2] 庞青[1] 宋燕州[1] 牟怡平[1] 刘昌[1] 

机构地区：[1]西安交通大学医学院第一附属医院肝胆外科,陕西西安710061 [2]湖北医药学院附属东风医院肝胆外科,湖北十堰442000

出　　处：《现代肿瘤医学》2015年第12期1691-1694,共4页Journal of Modern Oncology

摘　　要：目的:探讨幽门螺杆菌(Helicobacter pylori,Hp)感染与胰腺癌发病的相关性。方法:收集1990年-2013年国内外公开发表的关于幽门螺杆菌感染与胰腺癌发病相关性的病例对照研究的文献,应用Review Manager4.2软件Meta分析,计算合并优势比(odd ratio,OR值)及OR值95%可信区间(confidence interval,CI),倒漏斗图法定性评价发表性偏倚。结果:共7篇相关文献入选,总样本量2641例,其中胰腺癌947例,对照组1694例,Meta分析得出幽门螺杆菌感染与胰腺癌发病合并OR值为1.40(95%CI为1.04-1.89,Z=2.21,P=0.03)。本研究倒漏斗分析图形不对称,但经敏感性分析和计算失安全系数证明,发表性偏倚对结果有一定的影响。结论:幽门螺杆菌感染是胰腺癌发病的危险因素。Objective：To explore the relationship between Helicobacter pylori infection and the incidence of pan- creatic cancer. Methods：Collected at home and abroad from 1990 to 2013 published tiferatures on Helicobacter pylori infection associated with pancreatic cancer case -control study, to conduct the Meta -analysis. Results：The literature selected seven, with a total sample size 2641 cases, of which 947 cases of pancreatic cancer, 1694 cases of the control, combined OR values were statistically significant （ OR = 1.40,95 % CI 1.04 - 1.89, Z = 2. 21, P = 0.03 ）. Conclu- sion：Helicobacter pylori infection is a risk factor for pancreatic cancer.

关 键 词：幽门螺杆菌 胰腺癌 感染 META分析 

分 类 号：R735.9[医药卫生—肿瘤]