Yeast protein-protein interaction network model based on biological experimental data  

作　　者：Chunhong WANG Shuiming CAI Zengrong LIU Youwen CHEN 

机构地区：[1]Department of Mathematics, Shanghai University [2]Faculty of Science, Jiangsu University [3]Institute of Systems Biology, Shanghai University

出　　处：《Applied Mathematics and Mechanics(English Edition)》2015年第6期827-834,共8页应用数学和力学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(No.11172158)

摘　　要：Duplication and divergence have been widely recognized as the two domi- nant evolutionary forces in shaping biological networks, e.g., gene regulatory networks and protein-protein interaction （PPI） networks. It has been shown that the network growth models constructed on the principle of duplication and divergence can recapture the topo- logical properties of real PPI networks. However, such network models only consider the evolution processes. How to select the model parameters with the real biological experi- mental data has not been presented. Therefore, based on the real PPI network statistical data, a yeast PPI network model is constructed. The simulation results indicate that the topological characteristics of the constructed network model are well consistent with those of real PPI networks, especially on sparseness, scale-free, small-world, hierarchical modularity, and disassortativity.Duplication and divergence have been widely recognized as the two domi- nant evolutionary forces in shaping biological networks, e.g., gene regulatory networks and protein-protein interaction （PPI） networks. It has been shown that the network growth models constructed on the principle of duplication and divergence can recapture the topo- logical properties of real PPI networks. However, such network models only consider the evolution processes. How to select the model parameters with the real biological experi- mental data has not been presented. Therefore, based on the real PPI network statistical data, a yeast PPI network model is constructed. The simulation results indicate that the topological characteristics of the constructed network model are well consistent with those of real PPI networks, especially on sparseness, scale-free, small-world, hierarchical modularity, and disassortativity.

关 键 词：YEAST duplication-divergence protein-protein interaction （PPI） network disassortativity 

分 类 号：Q811.4[生物学—生物工程]