氨磷汀对盆腔肿瘤放疗患者肠道和膀胱黏膜的保护作用  

Protective Effect of Amifostine on the Gastric and Bladder Mucosa of Patients with Pelvic Radiotherapy Cancer

作　　者：马文[1] 蔡宏懿[1] 缪国英[1] 胡永果[1] 王建凯[1] 张利娟[1] 冯石芳[1] 

机构地区：[1]甘肃省人民医院放疗科,兰州730000

出　　处：《中国药房》2015年第17期2394-2396,共3页China Pharmacy

摘　　要：目的：考察氨磷汀对盆腔肿瘤患者放疗中肠道和膀胱黏膜的保护作用。方法：63例接受放疗的盆腔肿瘤患者按随机数字表法分为观察组（氨磷汀＋放疗,32例）和对照组（单纯放疗,31例）。观察并记录两组患者放射性膀胱炎和放射性直肠炎发生情况,并测定放疗前后外周血淋巴细胞中细胞凋亡因子Fas和Apo2.7表达情况。结果：观察组和对照组中各出现2例和3例放射性膀胱炎。观察组出现放射性直肠炎6例（其中1级4例、2级1例、3级1例）;对照组出现11例（其中1级1例、2级6例、3级4例）,观察组2-3级放射性直肠炎发生率低于对照组,差异具有统计学意义（P〈0-05）。放疗后,所有患者外周血淋巴细胞中凋亡因子Fas和Apo2.7表达均上调,但观察组Fas升高程度不如对照组明显,差异具有统计学意义（P〈0-05）。结论：氨磷汀对盆腔肿瘤放疗患者的肠道具有保护作用,其机制可能与抑制肠道黏膜细胞凋亡因子Fas的表达相关。OBJECTIVE： To investigate the protective effect of amifostine on the gastric and bladder of patients with pelvic can- cer in the radiotherapy. METHODS： 63 patients with pelvic cancer were randomly divided into observation group （amofistine treat- ment＋radiotherapy, n = 32） and control group （only radiotherapy, n = 31 ） by number. The incidence of radiocystitis and radioprocti- tis was recorded. The expressions of apoptotic factors Fas and Apo2.7 in peripheral blood lymphocytes before and after radiotherapy were determined. RESULTS： There were respectively 2 and 3 patients with radiocystitis in observation group and control group. 6 patients were found radioproctitis in observation group （4 of grade 1, 1 of grade 2 and 1 of grade 3）; 11 in control group （1 of grade 1, 6 of grade 2 and 4 of grade 3）. The incidence of grade 2-3 radioproctitis in observation group was lower than control group, with significant difference （P〈0-05）, After treatment, the expressions of apoptotic factors Fas and Apo2.7 in peripheral blood lymphocytes of all patients were increased, however, the increasing degree of Fas in observation group was not as obvious as control group （P〈0-05）. CONCLUSIONS： Amifostine has protective effects on the intestinal tract of patients with pelvic cancer in the radiotherapy by a mechanism that is related to the inhibition of apoptotic factors Fas expression in intestinal mucosa.

关 键 词：氨磷汀 盆腔肿瘤 放疗 肠道保护 FAS 

分 类 号：R737.3[医药卫生—肿瘤]