恶性疟原虫裂殖子表面蛋白等位基因分型研究进展  

Advances in the study of the allelic genotypes of merozoite surface proteins of Plasmodium falciparum

作　　者：张苍林[1,2] 杨亚明[2] 潘卫庆[1] 

机构地区：[1]第二军医大学热带传染病学教研室,上海200025 [2]云南省虫媒传染病防控研究重点实验室(筹备),云南省疟疾研究中心,云南省寄生虫病防治所,云南普洱665000

出　　处：《中国病原生物学杂志》2015年第4期373-376,共4页Journal of Pathogen Biology

摘　　要：疟疾是全球5大公共卫生问题之一,其中以恶性疟的危害更大。恶性疟原虫裂殖子表面蛋白与其入侵有关,是疟疾疫苗的重要候选抗原,恶性疟原虫裂殖子表面蛋白等位基因分型是当前研究的热点。本文对恶性疟裂殖子表面蛋白1,2等位基因研究进展作一综述。Malaria remains one of the world＇s five most significant public health issues. Plasmodium falciparum is responsible for most of the mortality due to malaria. During the merozoite stage of P. falciparum, proteins known as mer- ozoite surface proteins are found on the surface of merozoites. These merozoite surface proteins are involved in the process of merozoite invasion of erythrocytes and these proteins may represent potential components of malaria blood-stage vac cines. Merozoite surface proteins can be used to determine the allelic types of merozoite surface protein-1 （K1, MAD20, and RO33） and the allelic types of merozoite surface protein-2 （FC27 and 3D7） of P. falciparum. At present, research has focused on MSP-1 and MSP- 2. Thus article reviews advances in the study of MSP-1 and MSP-2.

关 键 词：疟原虫 恶性疟 裂殖子表面蛋白 等位基因 综述 

分 类 号：R382.31[医药卫生—医学寄生虫学]