溃疡性结肠炎患者粪便中Cal、MMP-9、MPO水平检测的临床研究  

Clinical studies of detection of fecal calprotectin,matrix metalloproteinase 9,myeloperoxidase in ulcerative colitis

作　　者：朱玉[1,2] 赵孝文[1] 丁浩[1] 刘晓昌[1] 梅俏[1] 许建明[1] 

机构地区：[1]安徽医科大学第一附属医院消化内科,合肥230022 [2]蚌埠医学院第一附属医院消化内科,蚌埠233004

出　　处：《安徽医科大学学报》2015年第6期847-849,854,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1308085MH146);杨森科学研究委员会中国分会研究基金(编号:2012JRCC消化02)

摘　　要：目的探讨溃疡性结肠炎(UC)患者粪便中钙卫蛋白(Cal)、基质金属蛋白酶9(MMP-9)、髓过氧化物酶(MPO)水平检测的临床意义。方法选择UC患者和正常对照者各50例,测定UC患者和正常对照者粪便中Cal、MMP-9、MPO水平。结果 UC活动期患者粪便中Cal、MMP-9、MPO水平显著高于缓解期患者和正常对照者,UC患者活动期轻中重度各组粪便中Cal、MMP-9、MPO水平比较差异有统计学意义(P<0.05,P<0.01);UC患者粪便中Cal、MMP-9、MPO水平与DAI评分显著相关(P<0.05)。结论粪便中Cal、MMP-9、MPO水平可作为UC患者疾病活动性评估的指标。Objective To investigate and discuss the clinical significance of detecting the level of fecal calprotectin （Cal）,matrix metalloproteinase-9（ MMP-9）,myelo-peroxidase（ MPO）in patients with ulcerative colitis（ UC）. Methods To measure the level of fecal Cal,MMP-9,MPO in 50 patients with UC before and after treatment,and the level in 50 healthy controls. Results The level of fecal Cal,MMP-9,MPO in active UC was significantly high-er than the level in remission UC and healthy controls;the difference of the level of fecal Cal,MMP-9,MPO in dif-ferent clinical severity groups of mild grade,moderate grade,severe grade was statistically significant（P 〈 0. 05,P〈 0. 01）. The level of fecal Cal,MMP-9,MPO also showed significant correlation with DAI in UC（P 〈 0. 05）. Conclusion The level of fecal Cal,MMP-9,MPO can be used as fecal makers for jurging activity in UC.

关 键 词：钙卫蛋白 基质金属蛋白酶 9 髓过氧化物酶 粪便 溃疡性结肠炎 

分 类 号：R574.1[医药卫生—消化系统]