活血益气补肾方对老年髋关节置换术后血液流变学参数及eNOS活性的影响  

Effect of Huoxue-Yiqi-Bushen prescription on hemorrheological parameters and endothelial nitric oxide synthase activity in aged patients at postoperative period of hip arthroplasty

作　　者：周剑鹏[1,2,3] 夏虹[3] 

机构地区：[1]南方医科大学研究生院,广东广州510515 [2]广州市中医医院骨科,广东广州510130 [3]广州军区广州总医院,广东广州510010

出　　处：《中国病理生理杂志》2015年第5期934-937,942,共5页Chinese Journal of Pathophysiology

基　　金：广州市医药卫生科技项目(No.20122A011007)

摘　　要：目的:观察活血益气补肾方对老年髋关节置换术后血液流变学参数及内皮型一氧化氮合酶(endothelial nitric oxide synthase,e NOS)活性的影响。方法:将符合标准的60例行髋关节置换术患者随机分为3组,每组20例。中医治疗组服用活血益气补肾方,肝素治疗组皮下注射依诺肝素,对照组服用阿司匹林肠溶片,检测3组术前、术后第1、10天血液e NOS、一氧化氮(nitric oxide,NO)及血液流变学的变化。结果:中医治疗组患者术后1 d血液e NOS、NO含量、全血黏度(whole blood viscosity,WBV)、血浆黏度(plasma viscosity,PV)、红细胞比积(hematocrit,HCT)、红细胞聚集系数(erythrocyte aggregation index,EAI)、刚性指数(index of rigidity,IR)、红细胞变形指数(erythrocyte deformation index,EDI)和红细胞电泳时间(erythrocyte electrophoresis time,EET)与其余2组比较,差异无统计学意义(P>0.05),术后10 d中医治疗组和对照组比较,血液e NOS和NO浓度明显高于对照组,血液流变学指标明显改善;中医治疗组和肝素治疗组比较,上述指标差异不显著(P>0.05)。结论:活血益气补肾方能有效提高老年髋关节置换术后血液e NOS和NO浓度,改善血液流变状态。AIM：To observe the effects of Huoxue-Yiqi-Bushen prescription on the hemorrheological parame-ters and endothelial nitric oxide synthase （ eNOS） activity in the aged patients with hip arthroplasty at postoperative period. METHODS：The patients （ n=60） operated by the same group of doctors were randomly divided into traditional Chinese medicine （ TCM） group, low-molecular-weight heparin （ LMWH） group and control group.Postoperative patients in TCM group were administrated with Huoxue-Yiqi-Bushen prescription.In LMWH group, 20 patients received LMWH postopera-tively.The patients in control group took aspirin enteric-coated tablets.The eNOS activity, nitric oxide （NO） content and hemorrheological parameters were observed before operation and 1 d and 10 d after operation.RESULTS： No significant difference of eNOS activity, NO content, whole blood viscosity （WBV）, plasma viscosity （PV）, hematocrit （HCT）, erythrocyte aggregation index （ EAI） , index of rigidity （ IR） , erythrocyte deformation index （ EDI） and erythrocyte electro-phoresis time （EET） between 3 groups 1 d after operation was found, while significant difference （P〈0.01） appeared be-tween TCM group and control group 10 d after operation.CONCLUSION：Huoxue-Yiqi-Bushen prescription can effective-ly increase eNOS and NO levels and improve hemorrheological parameters at postoperative period in aged patients with hip arthroplasty.

关 键 词：内皮型一氧化氮合酶 老年髋关节置换术 活血益气补肾方 

分 类 号：R363[医药卫生—病理学] R2-031[医药卫生—基础医学]