pEZR^(Thr567)在肺鳞癌中的表达及临床病理学意义  

Clinicopathological significance of pEZR^(Thr567) expression in lung squamous carcinoma

作　　者：张源[1] 金承龙[2] 王申桐 杨洋[1] 林贞花[1] 金铁峰[1] 

机构地区：[1]延边大学肿瘤研究所,吉林延吉133002 [2]延边大学附属医院皮肤科,吉林延吉133002

出　　处：《中国病理生理杂志》2015年第5期947-949,955,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.61371067)

摘　　要：目的:探讨第567位苏氨酸磷酸化的埃兹蛋白(p EZRThr567)在肺鳞癌、癌旁及正常肺组织中的表达及其临床病理学意义。方法:用免疫组化法检测p EZRThr567在肺癌、癌旁及正常肺组织中的表达,并分析其异常表达与临床病理学特点之间的相关性;用免疫荧光染色法检测p EZRThr567在肺鳞癌细胞EBC-1中的定位情况。结果:p EZRThr567蛋白在肺鳞癌组织中的表达明显高于癌旁组织和正常肺组织(P<0.01);p EZRThr567蛋白主要表达于细胞膜,且其表达与肿瘤分化程度、临床分期和有无淋巴结转移密切相关(P<0.05)。结论:p EZRThr567蛋白可作为肺鳞癌恶性进展的有效分子指标。AIM：To investigate the clinicopathological significance of the protein expression of phosphorylated ezrin at threonine 567 （ pEZRThr567 ） in lung squamous cell carcinoma, adjacent tissues and normal tissues.METHODS：pEZRThr567 protein was detected in lung squamous carcinoma, adjacent and normal tissues by the method of immunohisto-chemistry.The correlation of pEZRThr567 expression with clinicopathological parameters of lung squamous carcinomas was al-so analyzed.The localization of pEZRThr567 was detected by immunofluorescence staining in lung squamous cell line EBC-1. RESULTS：The protein expression of pEZRThr567 in lung squamous carcinoma was significantly higher than that in the adja-cent and normal lung tissues （P〈0.01）.pEZRThr567 mainly localized on the cell membrane, and its over-expression signi-ficantly correlated with the differentiation, clinical stage and lymph node metastasis in lung squamous carcinoma.CON-CLUSION：pEZRThr567 may be an effective biomarker for prediction of malignant potential and poor prognosis of lung cancer.

关 键 词：肺鳞癌 埃兹蛋白 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤] R730.5[医药卫生—临床医学]