细胞自噬在肝细胞癌侵袭转移中的作用及生物学意义  

Role of cell autophagy in invasion and metastasis of hepatocellular carcinoma

作　　者：朱朋飞[1] 秦建民[1] 

机构地区：[1]上海中医药大学附属普陀医院普外科,上海市200062

出　　处：《世界华人消化杂志》2015年第13期2029-2035,共7页World Chinese Journal of Digestology

基　　金：上海市普陀区肝胆胰重点专科基金资助项目;No.2012B162~~

摘　　要：肝细胞癌极易发生侵袭转移,目前尚未有特效防治方法,严重影响患者生存和预后.自噬是细胞生长发育、成熟分化及死亡的重要调控机制,肿瘤细胞生长需要的营养物质和氧不足时诱发自噬发生,通过降解细胞内蛋白质及细胞器提供营养及能量,利于肿瘤细胞生长和转移,但过度自噬导致细胞死亡.自噬在肝细胞癌发生与发展中具有双向调节作用,利用自噬发现更多的与肝细胞癌侵袭转移密切相关新的关键分子和治疗靶点,为肝细胞癌侵袭转移的防治提供新的理论依据和方向.Invasion and metastasis often occur in hepatocellular carcinoma. Since there have been no effective preventive or therapeutic modalities currently available, patients with hepatocellular carcinoma have a poor prognosis. Autophagy is an important mechanism that regulates and controls cell proliferation, differentiation and death.Autophagy can be induced when nutrients and oxygen of which tumor cells need are lack. Nutrients and energy can be supplied by degrading the intracellular organelles and proteins to maintain the tumor cell growth, but excessive autophagy leads to cell death. Autophagy is bidirectionally regulated during the occurrence and development of hepatocellular carcinoma. Studying cell autophagy may provide key molecules and therapeutic targets being closely related to invasion and metastasis of hepatocellular carcinoma, which will provide a new theoretical basis and direction for the prevention and treatment of invasion and metastasis of hepatocellular carcinoma.

关 键 词：肝细胞癌 侵袭 自噬 转移 

分 类 号：R735.7[医药卫生—肿瘤]