ATM激酶与视网膜病理性新生血管形成的研究进展  

Research advance of retinal pathological angiogenesis related to ATM protein kinase

作　　者：鲁理 郑志[2] 李春霞[3] 

机构地区：[1]蚌埠医学院研究生部,安徽省233030 [2]上海交通大学附属第一人民医院眼科 [3]上海市中西医结合医院眼科

出　　处：《中华眼科杂志》2015年第5期391-394,共4页Chinese Journal of Ophthalmology

摘　　要：共济失调毛细血管扩张症是一种常染色体隐性遗传性疾病，共济失调毛细血管扩张突变基因（ATM基因）是其致病基因。ATM基因编码产物ATM激酶主要分布于增殖细胞核中，并通过一系列信号通路调控DNA损伤应答和细胞凋亡等生命活动，在组织细胞衰老和肿瘤发生机制中发挥关键作用。近期研究发现，ATM激酶参与了病理性新生血管形成的调节，因此其在治疗视网膜新生血管性疾病中可能成为一个潜在的作用靶点。Ataxia-telangiectasia mutated（ATM） gene could cause ataxia telangiectasia which is an autosomal recessive disease. The ATM protein kinase encoded by the ATM gene mainly distributed in nucleus as a master regulator of the DNA damage response and apoptosis via cell signaling pathways. The ATM kinase plays a key role in the patbogenesis of cellular senescence and tumor genesis. Recently, some studies have indicated that ATM protein kinase is involved in pathological neovascularization, suggesting that it could be a novel potential therapeutic target in diseases associated with pathological angiogenesis.

关 键 词：视网膜新生血管化 共济失调毛细血管扩张突变蛋白质类 DNA损伤 氧化性应激 

分 类 号：R774.1[医药卫生—眼科]