上皮—间质转化在肿瘤发生发展中的作用研究进展  

Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis

作　　者：刘志娴[1] 魏尔清[1] 卢韵碧[1] 

机构地区：[1]浙江大学医学院药理学系

出　　处：《浙江大学学报（医学版）》2015年第2期211-216,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(81272594)

摘　　要：上皮—间质转化（ EMT ）是上皮细胞失去其形态和功能逐渐转化为间质样细胞的过程，与肿瘤复发和转移相关。 EMT的调控因素有很多，如E-钙黏蛋白、转化生长因子β、Wnt信号通路、微RNA及转录因子等。本文就目前关于EMT在肿瘤中的作用以及EMT的调节机制的研究进展做一综述，以期对肿瘤的治疗提供新的线索。Epithelial-mesenchymal transition （ EMT ） is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis .Many factors are involved in the regulation of EMT , such as E-cadherin , transforming growth factor-β, Wnt signaling pathway , microRNA and EMT-related transcription factors .This article reviews the research progress on EMT and the involved mechanisms , and thus to provide a new perspective on cancer therapy in the future .

关 键 词：肿瘤 钙黏着糖蛋白类 转录因子 间质细胞/病理学 上皮细胞/病理学 生物转化 综述 

分 类 号：R730.2[医药卫生—肿瘤]