CD4^+CD25^+调节性T细胞在肺癌中的表达及其临床意义  

Expression and significance of CD4^+CD25^+ regulatory T cells in patients with lung cancer

作　　者：杨兵[1] 潘莹[1] 蔡韶芳[1] 杜均祥[1] 龚五星[1] 

机构地区：[1]广东省珠海市人民医院中医科,519000

出　　处：《蚌埠医学院学报》2015年第5期627-628,共2页Journal of Bengbu Medical College

摘　　要：目的:探讨CD4+CD25+调节性T细胞在晚期肺癌中的表达及其临床意义。方法:应用流式细胞术分析42例肺癌患者(肺癌组)外周血CD4+CD25+调节性T细胞表达水平,与15名健康志愿者作对照。结果:肺癌组患者外周血CD4+CD25+调节性T细胞数量为(7.17±3.63)%,明显高于对照组的(4.25±2.11)%(P<0.01)。肺癌组患者外周血中调节性T细胞数量在病理类型间差异无统计学意义(P>0.05),晚期肺癌患者外周调节性T细胞数量高于早期患者(P<0.05)。结论:调节性T细胞在肺癌患者中比率明显升高,并与临床进展有关。Objective： To explore the expression and clinical significance of CD4^＋CD25^＋regulatory T cells in patients with lung cancer. Methods： The expression of CD4^＋CD25^＋regulatory T cells in the peripheral blood of 42 patients with lung cancer（ lung cancer group） and 15 healthy volunteers was determined by flow cytometry. Results： The number of CD4^＋CD25^＋regulatory T cells in the lung cancer group（ 7. 17 ± 3. 63） % was significantly higher than that in the healthy controls（ 4. 25 ± 2. 11） %（ P〈0. 01）. The level of CD4^＋CD25^＋regulatory T cells in the lung cancer patients with different pathological classifications had no statistically significant difference（ P〈0. 05）. The level of CD4^＋CD25^＋regulatory T cells in patients with advanced lung cancer was significantly higher than that in patients with early lung cancer（ P〈0. 05）. Conclusions： The proportion of CD4^＋CD25^＋regulatory T cells in the peripheral blood of patients with lung cancer is significantly increased,which is related to the progression of lung cancer.

关 键 词：肺肿瘤 CD4^+CD25^+调节性T细胞 流式细胞术 

分 类 号：R734.2[医药卫生—肿瘤]